Journal article
Current treatment paradigms in the management of lymphatic malformations
The Laryngoscope, Vol.121(1), pp.56-59
01/2011
DOI: 10.1002/lary.20768
PMID: 21046541
Abstract
Lymphatic malformations (LMs) are benign abnormalities of the lymphatic system that can be significantly infiltrative and intimately involve critical structures of the head and neck, making their management difficult. Historically, LMs have been managed by surgical excision, but this treatment approach results in significant morbidity and a high recurrence rate secondary to subtotal resection. As an alternative to surgery a variety of drugs have been used as intralesional sclerosants and immunotherapeutics. These agents offer improved outcomes with lower morbidity as compared to surgery when targeted to macrocystic LMs. However intralesional therapy is not effective in the treatment of microcystic LMs. The development of treatments that are effective for all types of LMs will require further understanding of lymphangiogenesis and the pathogenesis of LMs. Laryngoscope, 2011
Details
- Title: Subtitle
- Current treatment paradigms in the management of lymphatic malformations
- Creators
- John P RentonRichard J. H Smith
- Resource Type
- Journal article
- Publication Details
- The Laryngoscope, Vol.121(1), pp.56-59
- DOI
- 10.1002/lary.20768
- PMID
- 21046541
- NLM abbreviation
- Laryngoscope
- ISSN
- 0023-852X
- eISSN
- 1531-4995
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- Number of pages
- 4
- Language
- English
- Date published
- 01/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006335902771
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