Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States

Hilmar Wisplinghoff; Harald Seifert; Richard P Wenzel; Michael B Edmond

doi:10.1086/374339

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Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States

Journal article

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Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States

Hilmar Wisplinghoff, Harald Seifert, Richard P Wenzel and Michael B Edmond

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.36(9), pp.1103-1110

05/01/2003

DOI: 10.1086/374339

PMID: 12715303

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Abstract

A total of 2340 patients with underlying malignancy were identified among 22,631 episodes of nosocomial bloodstream infections (BSIs) in a prospectively collected database for 49 hospitals in the United States (Surveillance and Control of Pathogens of Epidemiologic Importance [SCOPE] Project). Data were obtained for the period of March 1995 through February 2001. Gram-positive organisms accounted for 62% of all BSIs in 1995 and for 76% in 2000 (P<.001), and gram-negative organisms accounted for 22% and 14% of all BSIs for these years, respectively. Neutropenia was observed in 30% of patients, so neutropenic and nonneutropenic patients were compared. In both, the predominant pathogens were coagulase-negative staphylococci (32% of isolates recovered from neutropenic patients and 30% of isolates recovered from nonneutropenic patients). The source of BSI was not determined for 57% of patients. The crude mortality rate was 36% for neutropenic patients and 31% for nonneutropenic patients.

United States - epidemiology

Prospective Studies

Humans

Middle Aged

Bacteremia - complications

Bacteria - drug effects

Male

Cross Infection - complications

Bacteremia - microbiology

Microbial Sensitivity Tests

Neutropenia - etiology

Cross Infection - microbiology

Adolescent

Adult

Bacteremia - epidemiology

Female

Aged

Hematologic Neoplasms - complications

Methicillin Resistance

Cross Infection - epidemiology

Details

Title: Subtitle: Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States
Creators: Hilmar Wisplinghoff - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany. h.wisplinghoff@uni-koeln.de
Harald Seifert
Richard P Wenzel
Michael B Edmond
Resource Type: Journal article
Publication Details: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.36(9), pp.1103-1110
DOI: 10.1086/374339
PMID: 12715303
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: United States
Language: English
Date published: 05/01/2003
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9983905647002771

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