Journal article
Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis
Current rheumatology reports, Vol.14(2), pp.130-141
04/2012
DOI: 10.1007/s11926-012-0239-5
PMCID: PMC3656493
PMID: 22359228
Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory disorder that primarily affects children. Its hallmark is recurring episodes of sterile osteomyelitis. The clinical presentation is insidious onset of bone pain with or without fever. Laboratory studies typically reveal nonspecific evidence of inflammation. Radiologic imaging and histologic appearance resemble those of infectious osteomyelitis. There is a strong association with inflammatory disorders of the skin and intestinal tract in affected individuals and their close relatives, suggesting a shared pathophysiology and supporting a genetic component to disease susceptibility. Two genetic syndromes have CRMO as a prominent phenotype-Majeed syndrome and deficiency of the interleukin-1 receptor antagonist-and suggest that interleukin-1 may be a key cytokine in disease pathogenesis. This review briefly summarizes the main clinical and radiologic aspects of the disease and then focuses on genetics and pathophysiology and provides an update on treatment.
Details
- Title: Subtitle
- Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis
- Creators
- Polly J Ferguson - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA. polly-ferguson@uiowa.eduMonica Sandu
- Resource Type
- Journal article
- Publication Details
- Current rheumatology reports, Vol.14(2), pp.130-141
- Publisher
- United States
- DOI
- 10.1007/s11926-012-0239-5
- PMID
- 22359228
- PMCID
- PMC3656493
- ISSN
- 1523-3774
- eISSN
- 1534-6307
- Grant note
- 1R01AR059703-01A1 / NIAMS NIH HHS R01 AR059703 / NIAMS NIH HHS R01 AR059703-01A1 / NIAMS NIH HHS
- Language
- English
- Date published
- 04/2012
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984065840202771
Metrics
24 Record Views