Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778)

Yongsheng Che; James B Gloer; Donald T Wicklow

doi:10.1021/ol0498186

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Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778)

Journal article

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Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778)

Yongsheng Che, James B Gloer and Donald T Wicklow

Organic letters, Vol.6(8), pp.1249-1252

04/15/2004

DOI: 10.1021/ol0498186

PMID: 15070309

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Abstract

Curvicollides A-C (1-3) have been obtained from cultures of an isolate of Podospora curvicolla (NRRL 25778) that colonized a sclerotium of Aspergillus flavus. The structures of these compounds were elucidated by analysis of one- and two-dimensional NMR data. The lead compound (1) showed antifungal activity against A. flavus and Fusarium verticillioides. [structure: see text]

Antifungal Agents - chemistry

Antifungal Agents - isolation & purification

Antifungal Agents - pharmacology

Ascomycota

Aspergillus flavus - drug effects

Fusarium - drug effects

Lactones - isolation & purification

Lactones - pharmacology

Microbial Sensitivity Tests

Molecular Structure

Nuclear Magnetic Resonance, Biomolecular

Podospora - chemistry

Details

Title: Subtitle: Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778)
Creators: Yongsheng Che - Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
James B Gloer
Donald T Wicklow
Resource Type: Journal article
Publication Details: Organic letters, Vol.6(8), pp.1249-1252
DOI: 10.1021/ol0498186
PMID: 15070309
ISSN: 1523-7060
eISSN: 1523-7052
Language: English
Date published: 04/15/2004
Academic Unit: Chemistry
Record Identifier: 9984216697002771

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