Logo image
Back
Cutaneous Manifestations of Human and Murine Leishmaniasis
Journal article   Open access   Peer reviewed

Cutaneous Manifestations of Human and Murine Leishmaniasis

Breanna M Scorza, Edgar M Carvalho and Mary E Wilson
International journal of molecular sciences, Vol.18(6), p.1296
06/18/2017
DOI: 10.3390/ijms18061296
PMCID: PMC5486117
PMID: 28629171
url
https://doi.org/10.3390/ijms18061296View
Published (Version of record) Open Access

Abstract

The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Infections are initiated when a sand fly vector inoculates parasites into the skin of a mammalian host. causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.
 Animals Leishmaniasis, Cutaneous - parasitology Humans Leishmaniasis, Cutaneous - pathology Skin - parasitology Mice Leishmaniasis, Cutaneous - immunology Leishmania - isolation & purification Skin - pathology Skin - immunology

Details

Metrics

29 Record Views
171 Times Cited - Web of Science
Logo image