Journal article
Cutaneous and immunologic reactions to phenytoin
Journal of the American Academy of Dermatology, Vol.18(4), pp.721-741
1988
DOI: 10.1016/S0190-9622(88)70096-1
PMID: 2967311
Abstract
Phenytoin (diphenylhydantoin; Dilantin) is a highly effective and widely prescribed anticonvulsant and antiarrhythmic agent, Since 1938 it has been invaluable in the treatment of grand mal and psychomotor epilepsy. Hydantoin derivatives have been used medicinally for more than a half-century. In recent years dermatologists have broadened the indications for phenytoin use to include recessive dystrophic epidermolysis bullosa, linear scleroderma, and pachyonychia congenita. In spite of widespread use and popularity, it is interesting that the frequency of complications relating to drug therapy remains low, relatively speaking. Nevertheless, a broad spectrum of cutaneous and immunologic reactions to phenytoin have been reported. These range from tissue proliferative syndromes (side effects), drug hypersensitivity syndromes (allergic effects), and a possible linkage with lymphoma (idiosyncratic effects). Therapeutic and toxic reactions to this commonly prescribed drug are comprehensively reviewed, analyzed, and summarized in this monograph. © 1988, All rights reserved.
Details
- Title: Subtitle
- Cutaneous and immunologic reactions to phenytoin
- Creators
- A. K Silverman - University of RochesterJ Fairley - University of RochesterR. C Wong - University of Rochester
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Dermatology, Vol.18(4), pp.721-741
- DOI
- 10.1016/S0190-9622(88)70096-1
- PMID
- 2967311
- NLM abbreviation
- J Am Acad Dermatol
- ISSN
- 0190-9622
- eISSN
- 1097-6787
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1988
- Academic Unit
- Dermatology
- Record Identifier
- 9984296214302771
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