Cutaneous melanocytic tumor with CRTC1 :: TRIM11 fusion and prominent epidermal involvement: A case report

Blake E. Vest; Christina L. Harview; Vincent Liu; Brian L. Swick; Kristen G. Berrebi; Shantel Olivares; Mary S. Stone; Michael R. Sargen; Pedram Gerami

doi:10.1111/cup.14287

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Cutaneous melanocytic tumor with CRTC1 :: TRIM11 fusion and prominent epidermal involvement: A case report

Journal article

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Cutaneous melanocytic tumor with CRTC1 :: TRIM11 fusion and prominent epidermal involvement: A case report

Blake E. Vest, Christina L. Harview, Vincent Liu, Brian L. Swick, Kristen G. Berrebi, Shantel Olivares, Mary S. Stone, Michael R. Sargen and Pedram Gerami

Journal of cutaneous pathology, Vol.49(12), pp.1025-1030

06/25/2022

DOI: 10.1111/cup.14287

PMCID: PMC10086857

PMID: 35751643

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Abstract

Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.

Details

Title: Subtitle: Cutaneous melanocytic tumor with CRTC1 :: TRIM11 fusion and prominent epidermal involvement: A case report
Creators: Blake E. Vest - University of Iowa Hospitals and Clinics
Christina L. Harview - University of Iowa
Vincent Liu - University of Iowa Hospitals and Clinics
Brian L. Swick - University of Iowa
Kristen G. Berrebi - University of Iowa
Shantel Olivares - Northwestern University
Mary S. Stone - University of Iowa
Michael R. Sargen - National Institutes of Health
Pedram Gerami - Northwestern University
Resource Type: Journal article
Publication Details: Journal of cutaneous pathology, Vol.49(12), pp.1025-1030
DOI: 10.1111/cup.14287
PMID: 35751643
PMCID: PMC10086857
NLM abbreviation: J Cutan Pathol
ISSN: 0303-6987
eISSN: 1600-0560
Grant note: DOI: 10.13039/100011541, name: Division of Cancer Epidemiology and Genetics, National Cancer Institute; DOI: 10.13039/100000002, name: National Institutes of Health
Language: English
Date published: 06/25/2022
Academic Unit: Dermatology; Stead Family Department of Pediatrics; Pathology
Record Identifier: 9984296210602771

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