Journal article
Cutting Edge: Antilisterial Activity of CD8+T Cells Derived from TNF-Deficient and TNF/Perforin Double-Deficient Mice
The Journal of immunology (1950), Vol.165(1), pp.5-9
07/01/2000
DOI: 10.4049/jimmunol.165.1.5
PMID: 10861027
Abstract
The mechanisms by which CD8+ T cells mediate immunity against bacterial pathogens remain largely unknown. Perforin-dependent cytolysis plays a role, but is not required for CD8+ T cell-mediated immunity against Listeria monocytogenes. TNF is essential for CD8+ T cell immunity to L. monocytogenes, but the cellular source of TNF is undefined. TNF-deficient and TNF/perforin double-deficient mice were used to generate CD8+ T cells specific for an L. monocytogenes-derived Ag. Wild-type and TNF-deficient CD8+ T cells mediated antilisterial immunity in wild-type but not TNF-deficient host mice, revealing that CD8+ T cell-derived TNF is not required for CD8+ T cell-mediated antilisterial immunity, but demonstrating a role for TNF derived from other cell types. TNF/perforin double-deficient CD8+ T cells mediated antilisterial immunity in the liver, but not in the spleen, of wild-type recipient mice, suggesting that perforin-independent immunity in the spleen requires CD8+ T cell-derived TNF.
Details
- Title: Subtitle
- Cutting Edge: Antilisterial Activity of CD8+T Cells Derived from TNF-Deficient and TNF/Perforin Double-Deficient Mice
- Creators
- Douglas W WhiteVladimir P BadovinacGeorge KolliasJohn T Harty
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.165(1), pp.5-9
- DOI
- 10.4049/jimmunol.165.1.5
- PMID
- 10861027
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 07/01/2000
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047859002771
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