Cutting Edge: Antitumor Immunity by Pathogen-Specific CD8 T Cells in the Absence of Cognate Antigen Recognition

Derek B Danahy; Roger R Berton; Vladimir P Badovinac

doi:10.4049/jimmunol.1901172

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Cutting Edge: Antitumor Immunity by Pathogen-Specific CD8 T Cells in the Absence of Cognate Antigen Recognition

Journal article

Peer reviewed

Cutting Edge: Antitumor Immunity by Pathogen-Specific CD8 T Cells in the Absence of Cognate Antigen Recognition

Derek B Danahy, Roger R Berton and Vladimir P Badovinac

The Journal of immunology (1950), Vol.204(6), pp.1431-1435

03/15/2020

DOI: 10.4049/jimmunol.1901172

PMID: 32051220

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https://www.ncbi.nlm.nih.gov/pmc/articles/7310247View

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Abstract

Cancer prognosis often correlates with the number of tumor-infiltrating CD8 T cells, but many of these cells recognize pathogens that commonly infect humans. The contribution of pathogen-specific "bystander" CD8 T cells to antitumor immunity remains largely unknown. Inflammatory cytokines are sufficient for memory CD8 T cell activation and gain of effector functions, indicating tumor-derived inflammation could facilitate pathogen-specific CD8 T cells to participate in tumor control. In this study, we show in contrast to tumor-specific CD8 T cells that pathogen-specific primary memory CD8 T cells inside tumor were not able to exert their effector functions and influence tumor progression. However, infection-induced memory CD8 T cells with defined history of repeated Ag encounters (i.e., quaternary memory) showed increased sensitivity to tumor-derived inflammation that resulted in activation, gain of effector functions, and better control of tumor growth. Thus, memory CD8 T cells with heightened ability to recognize environmental inflammatory stimuli can contribute to antitumor immunity in the absence of cognate Ag recognition.

Details

Title: Subtitle: Cutting Edge: Antitumor Immunity by Pathogen-Specific CD8 T Cells in the Absence of Cognate Antigen Recognition
Creators: Derek B Danahy - University of Iowa
Roger R Berton - University of Iowa
Vladimir P Badovinac - University of Iowa
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.204(6), pp.1431-1435
DOI: 10.4049/jimmunol.1901172
PMID: 32051220
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Language: English
Date published: 03/15/2020
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984180919602771

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