Journal article
Cutting Edge: CTLA-4–B7 Interaction Suppresses Th17 Cell Differentiation
The Journal of immunology (1950), Vol.185(3), pp.1375-1378
08/01/2010
DOI: 10.4049/jimmunol.0903369
PMCID: PMC2915549
PMID: 20601598
Abstract
Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28–B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4–B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4–B7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to CD28
−/−
mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. The enhanced disease susceptibility is mediated by heightened Th17 responses. With these results, we are the first to demonstrate that CTLA-4–B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity.
Details
- Title: Subtitle
- Cutting Edge: CTLA-4–B7 Interaction Suppresses Th17 Cell Differentiation
- Creators
- Haiyan Ying - Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, ShanghaiLifen Yang - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaGuilin Qiao - Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637Zhenping Li - Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637Li Zhang - Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637Fei Yin - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaDong Xie - Laboratory of Molecular Cancer Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, ShanghaiJian Zhang - Committee on Immunology, University of Chicago, Chicago, IL 60637
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.185(3), pp.1375-1378
- DOI
- 10.4049/jimmunol.0903369
- PMID
- 20601598
- PMCID
- PMC2915549
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 08/01/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984046933402771
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