Journal article
Cutting Edge: Ectopic Expression of the Chemokine TCA4/SLC Is Sufficient to Trigger Lymphoid Neogenesis
The Journal of immunology (1950), Vol.164(8), pp.3955-3959
04/15/2000
DOI: 10.4049/jimmunol.164.8.3955
PMID: 10754285
Abstract
To test whether accumulation of naive lymphocytes is sufficient to trigger lymphoid development, we generated mice with islet expression of the chemokine TCA4/SLC. This chemokine is specific for naive lymphocytes and mature dendritic cells (DC) which express the CCR7 receptor. Islets initially developed accumulations of T cells with DC, with scattered B cells at the perimeter. These infiltrates consolidated into organized lymphoid tissue, with high endothelial venules and stromal reticulum. Infiltrate lymphocytes showed a naive CD44(low) CD25- CD69- phenotype, though half were CD62L negative. When backcrossed to RAG-1 knockout, DC were not recruited. Interestingly, islet lymphoid tissue developed in backcrosses to Ikaros knockout mice despite the absence of normal peripheral nodes. Our results indicate that TCA4/SLC can induce the development and organization of lymphoid tissue through diffential recruitment of T and B lymphocytes and secondary effects on stromal cell development.
Details
- Title: Subtitle
- Cutting Edge: Ectopic Expression of the Chemokine TCA4/SLC Is Sufficient to Trigger Lymphoid Neogenesis
- Creators
- Lian Fan - Scripps Research InstituteChristina R. Reilly - Scripps Research InstituteYi Luo - Harvard UniversityMartin E. Dorf - Harvard UniversityDavid Lo - Scripps Research Institute
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.164(8), pp.3955-3959
- DOI
- 10.4049/jimmunol.164.8.3955
- PMID
- 10754285
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 04/15/2000
- Academic Unit
- Urology
- Record Identifier
- 9984320854102771
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