Journal article
Cutting Edge: OFF Cycling of TNF Production by Antigen-Specific CD8+ T Cells Is Antigen Independent
The Journal of immunology (1950), Vol.165(10), pp.5387-5391
11/15/2000
DOI: 10.4049/jimmunol.165.10.5387
PMID: 11067887
Abstract
Although they are known for their capacity to kill infected cells, Ag-specific CD8(+) T cells elaborate other effector mechanisms, including TNF and IFN-gamma, that contribute to defense against infection. Ag-specific CD8(+) T cells rapidly turn ON and turn OFF IFN-gamma production in direct response to Ag contact, presumably to minimize the potential immunopathology that could result from inappropriate secretion of this inflammatory mediator. In this study, we show, using in vitro propagated and directly ex vivo-analyzed Ag-specific CD8(+) T cells, that in contrast to Ag-dependent ON/OFF cycling of IFN-gamma production, the cessation of TNF production by the same IFN-gamma producing cells is rapid and Ag independent.
Details
- Title: Subtitle
- Cutting Edge: OFF Cycling of TNF Production by Antigen-Specific CD8+ T Cells Is Antigen Independent
- Creators
- Vladimir P BadovinacGail A CorbinJohn T Harty
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.165(10), pp.5387-5391
- DOI
- 10.4049/jimmunol.165.10.5387
- PMID
- 11067887
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English
- Date published
- 11/15/2000
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047617602771
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