Journal article
Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites
The Journal of immunology (1950), Vol.207(11), pp.2631-2635
12/01/2021
DOI: 10.4049/jimmunol.2100818
PMCID: PMC8612975
PMID: 34716185
Abstract
Radiation-attenuated sporozoite (RAS) vaccination offers hope for global malaria control through induction of protective liver-stage-specific memory CD8 T cells. Effective RAS vaccination regimens exist; however, widespread implementation remains unfeasible. A key difficulty resides in the need to administer three or more doses i.v. to achieve sufficient immunity. Strategies to reduce the number of RAS doses are therefore desirable. Here we used mice to model human immune responses to a single, suboptimal weight-normalized RAS dose administered i.v. followed by subunit vaccination to amplify liver-stage-specific memory CD8 T cells. RAS+subunit prime-boost regimens increased the numbers of liver-stage-specific memory CD8 T cells to a level greater than is present after one RAS vaccination. Both i.v. and i.m. subunit vaccine delivery induced immunity in mice, and many vaccinated mice completely cleared liver infection. These findings are particularly relevant to human vaccine development because RAS+subunit prime-boost vaccination would reduce the logistical challenges of multiple RAS-only immunizations.
Copyright © 2021 by The American Association of Immunologists, Inc.
Details
- Title: Subtitle
- Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites
- Creators
- Mitchell N Lefebvre - University of IowaLisa L Drewry - University of Iowa, PathologyLecia L Pewe - University of IowaLisa S HancoxArturo Reyes-SandovalJohn T Harty - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.207(11), pp.2631-2635
- DOI
- 10.4049/jimmunol.2100818
- PMID
- 34716185
- PMCID
- PMC8612975
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Grant note
- T32 AI007485/AI/NIAID NIH HHS/United States R01 AI100527/AI/NIAID NIH HHS/United States R01 AI085515/AI/NIAID NIH HHS/United States R01 AI114543/AI/NIAID NIH HHS/United States T32 GM007337/GM/NIGMS NIH HHS/United States P30 CA086862/CA/NCI NIH HHS/United States R01 AI042767/AI/NIAID NIH HHS/United States
- Language
- English
- Date published
- 12/01/2021
- Academic Unit
- University of Iowa; Pathology
- Record Identifier
- 9984199922002771
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