Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo

Gabriel R Starbeck-Miller; Vladimir P Badovinac; Daniel L Barber; John T Harty

doi:10.4049/jimmunol.1302232

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Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo

Journal article

Peer reviewed

Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo

Gabriel R Starbeck-Miller, Vladimir P Badovinac, Daniel L Barber and John T Harty

The Journal of immunology (1950), Vol.192(1), pp.35-39

01/01/2014

DOI: 10.4049/jimmunol.1302232

PMCID: PMC3874719

PMID: 24285839

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Abstract

During reinfection, high-affinity IgG Abs form complexes with both soluble Ag and Ag displayed on the surface of infected cells. These interactions regulate cellular activation of both innate cells and B cells, which express specific combinations of activating FcγRs (FcγRI, FcγRIII, FcγRIV) and/or the inhibitory FcγR (FcγRIIB). Direct proof for functional expression of FcγR by Ag-specific CD8 T cells is lacking. In this article, we show that the majority of memory CD8 T cells generated by bacterial or viral infection express only FcγRIIB, and that FcγRIIB could be detected on previously activated human CD8 T cells. Of note, FcγR stimulation during in vivo Ag challenge not only inhibited the cytotoxicity of memory CD8 T cells against peptide-loaded or virus-infected targets, but FcγRIIB blockade during homologous virus challenge enhanced the secondary CD8 T cell response. Thus, memory CD8 T cells intrinsically express a functional FcγRIIB, permitting Ag-Ab complexes to regulate secondary CD8 T cell responses.

Lymphocytic choriomeningitis virus - immunology

Cell Line

Humans

Gene Expression Regulation

Lymphocytic Choriomeningitis - immunology

Receptors, IgG - metabolism

Mice, Knockout

Receptors, IgG - genetics

Animals

CD8-Positive T-Lymphocytes - metabolism

Antigens - immunology

Mice

Epitopes, T-Lymphocyte - immunology

CD8-Positive T-Lymphocytes - immunology

Immunologic Memory - genetics

Cytotoxicity, Immunologic

Details

Title: Subtitle: Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo
Creators: Gabriel R Starbeck-Miller - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242
Vladimir P Badovinac
Daniel L Barber
John T Harty
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.192(1), pp.35-39
DOI: 10.4049/jimmunol.1302232
PMID: 24285839
PMCID: PMC3874719
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: T32 AI007610 / NIAID NIH HHS R01 AI095178 / NIAID NIH HHS R01 AI083286 / NIAID NIH HHS AI083286 / NIAID NIH HHS AI096850 / NIAID NIH HHS R21 AI096850 / NIAID NIH HHS T32 AI007511 / NIAID NIH HHS R37 AI042767 / NIAID NIH HHS AI85515 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS AI95178 / NIAID NIH HHS AI96850 / NIAID NIH HHS T32 AI 007511 / NIAID NIH HHS AI42676 / NIAID NIH HHS AI90850 / NIAID NIH HHS R01 AI085515 / NIAID NIH HHS
Language: English
Date published: 01/01/2014
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984047798602771

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