Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization

Nathan W Schmidt; John T Harty

doi:10.4049/jimmunol.1003949

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Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization

Journal article

Peer reviewed

Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization

Nathan W Schmidt and John T Harty

The Journal of immunology (1950), Vol.186(7), pp.3836-3840

04/01/2011

DOI: 10.4049/jimmunol.1003949

PMCID: PMC3074438

PMID: 21357257

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Abstract

Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T cells. However, infections with unrelated pathogens, as may occur in areas endemic to malaria, can dramatically decrease pre-existing memory CD8 T cells. It remains unknown whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells and thus limit the duration of antimalarial immunity generated by subunit vaccination. We show that P. berghei circumsporozoite-specific memory CD8 T cells underwent significant attrition in numbers in mice subjected to unrelated infections. Attrition was associated with preferential loss of effector memory CD8 T cells and reduced immunity to P. berghei sporozoite challenge. However, and of relevance to deployment of Plasmodium vaccines in areas endemic to malaria, attrition of memory CD8 T cells was reversed by booster immunization, which restored protection. These data suggest that regular booster immunizations may be required to sustain protective vaccine-induced Plasmodium-specific memory CD8 T cells in the face of attrition caused by unrelated infections.

Coronavirus Infections - prevention & control

Plasmodium berghei - immunology

CD8-Positive T-Lymphocytes - pathology

Dendritic Cells - immunology

CD8-Positive T-Lymphocytes - parasitology

Listeriosis - prevention & control

Lymphocytic Choriomeningitis - immunology

Listeriosis - immunology

Malaria Vaccines - immunology

Malaria Vaccines - therapeutic use

Protozoan Proteins - administration & dosage

Malaria - immunology

Immunization, Secondary - methods

Immunity, Innate

Coronavirus Infections - immunology

Malaria - prevention & control

Vaccinia - prevention & control

Animals

Malaria Vaccines - administration & dosage

Lymphocytic Choriomeningitis - prevention & control

Malaria - pathology

Vaccinia - immunology

Immunologic Memory

Mice

Mice, Inbred BALB C

CD8-Positive T-Lymphocytes - immunology

Dendritic Cells - transplantation

Lymphocyte Depletion - methods

Protozoan Proteins - immunology

Details

Title: Subtitle: Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization
Creators: Nathan W Schmidt - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
John T Harty
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.186(7), pp.3836-3840
DOI: 10.4049/jimmunol.1003949
PMID: 21357257
PMCID: PMC3074438
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: R01 AI085515-02 / NIAID NIH HHS F32 AI084329 / NIAID NIH HHS AI085515 / NIAID NIH HHS 1-F32-AI084329 / NIAID NIH HHS F32 AI084329-01 / NIAID NIH HHS R01 AI085515 / NIAID NIH HHS
Language: English
Date published: 04/01/2011
Academic Unit: Pathology
Record Identifier: 9984047796102771

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