Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation

Ali Jabbari; John T Harty

doi:10.4049/jimmunol.175.8.4829

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Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation

Journal article

Peer reviewed

Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation

Ali Jabbari and John T Harty

The Journal of immunology (1950), Vol.175(8), pp.4829-4833

10/15/2005

DOI: 10.4049/jimmunol.175.8.4829

PMID: 16210583

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Abstract

Memory T cells do not require self-peptide/MHC (spMHC) complexes to survive long term in vivo. However, memory CD4 T cells lose the ability to reject skin grafts when transiently placed in an environment in which these low-level TCR stimulations are absent. Whether or not spMHC alters the ability of CD8 T cells to respond to stimulation in vivo remains unknown. Here, we show that memory CD8 T cells retain the ability to respond to dendritic cell-mediated stimulation after adoptive transfer into either TAP(-/-) (MHC class I-deficient) or wild-type mice. Surprisingly, naive CD8 T cells, which fail to undergo homeostatic proliferation and erode in number in the absence of MHC class I, also retain the ability to respond to dendritic cell-mediated antigenic stimulation for at least 1 wk after transfer into TAP(-/-) mice. These findings suggest a differential requirement for spMHC signals for maintenance of CD8 T cell function and homeostatic proliferation.

Cell Proliferation

Mice, Inbred C57BL

Cells, Cultured

Histocompatibility Antigens Class I - physiology

Homeostasis - immunology

Mice, Transgenic

Mice, Knockout

Autoantigens - physiology

Animals

Immunologic Memory

Mice

Receptors, Antigen, T-Cell - genetics

CD8-Positive T-Lymphocytes - immunology

Details

Title: Subtitle: Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation
Creators: Ali Jabbari - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
John T Harty
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.175(8), pp.4829-4833
DOI: 10.4049/jimmunol.175.8.4829
PMID: 16210583
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: AI42767 / NIAID NIH HHS AI50073 / NIAID NIH HHS AI46653 / NIAID NIH HHS AI59752 / NIAID NIH HHS
Language: English
Date published: 10/15/2005
Academic Unit: Dermatology; Pathology
Record Identifier: 9984025445002771

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