Cutting edge: hemokinin has substance P-like function and expression in inflammation

Ahmed Metwali; Arthur M Blum; David E Elliott; Tommy Setiawan; Joel V Weinstock

doi:10.4049/jimmunol.172.11.6528

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Cutting edge: hemokinin has substance P-like function and expression in inflammation

Journal article

Open access

Peer reviewed

Cutting edge: hemokinin has substance P-like function and expression in inflammation

Ahmed Metwali, Arthur M Blum, David E Elliott, Tommy Setiawan and Joel V Weinstock

The Journal of immunology (1950), Vol.172(11), pp.6528-6532

06/01/2004

DOI: 10.4049/jimmunol.172.11.6528

PMID: 15153465

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Abstract

Substance P (SP) belongs to the tachykinin family of molecules. SP, cleaved from preprotachykinin A, is a neuropeptide and a proinflammatory leukocyte product. SP engages neurokinin 1 receptor (NK-1R) to stimulate cells. Hemokinin (HK) is another tachykinin that binds NK-1R. HK comes from preprotachykinin C, which is distinct from preprotachykinin A. We determined whether HK functions like SP at inflammatory sites. Preprotachykinin C mRNA was in murine schistosome granulomas and intestinal lamina propria mononuclear cells. Granuloma T cells and macrophages expressed preprotachykinin C mRNA. HK bound granuloma T cell NK-1R with high affinity. SP and HK stimulated IFN-gamma production with equal potency. NK-1R antagonist blocked the effect of SP and HK on IFN-gamma secretion. Thus, both HK and SP are expressed at sites of chronic inflammation and share cell origin, receptor, and immunoregulatory function. Two distinct but functionally overlapping tachykinins govern inflammation through NK-1R at sites of chronic inflammation.

Cell Line

Protein Precursors - genetics

Mice, Inbred C57BL

Inflammation - metabolism

Animals

Tachykinins - genetics

Protein Precursors - physiology

Substance P - physiology

Mice, Inbred CBA

Receptors, Neurokinin-1 - metabolism

Mice

Interferon-gamma - biosynthesis

Tachykinins - physiology

Details

Title: Subtitle: Cutting edge: hemokinin has substance P-like function and expression in inflammation
Creators: Ahmed Metwali - Department of Internal Medicine, Division of Gastroenterology-Hepatology, University of Iowa, Iowa City, IA 52242, USA
Arthur M Blum
David E Elliott
Tommy Setiawan
Joel V Weinstock
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.172(11), pp.6528-6532
DOI: 10.4049/jimmunol.172.11.6528
PMID: 15153465
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: DK38327 / NIDDK NIH HHS DK58755 / NIDDK NIH HHS DK25295 / NIDDK NIH HHS DK07663 / NIDDK NIH HHS
Language: English
Date published: 06/01/2004
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094663602771

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