Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine

Bram Slütter; Lecia L Pewe; Peter Lauer; John T Harty

doi:10.4049/jimmunol.1202790

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Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine

Journal article

Peer reviewed

Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine

Bram Slütter, Lecia L Pewe, Peter Lauer and John T Harty

The Journal of immunology (1950), Vol.190(8), pp.3854-3858

04/15/2013

DOI: 10.4049/jimmunol.1202790

PMCID: PMC3622175

PMID: 23467935

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Abstract

Memory CD8 T cells recognizing conserved proteins from influenza A virus (IAV), such as nucleoprotein, have the potential to provide protection in individuals who lack the proper neutralizing Abs. In this study, we show that the most potent CD8 T cell-inducing influenza vaccine on the market (Flumist) does not induce sufficient numbers of cross-reactive CD8 T cells to provide substantial protection against lethal nonhomologous IAV challenge. However, Flumist-primed CD8 T cells rapidly acquire memory characteristics and can respond to short-interval boosting to greatly enlarge the IAV-specific memory pool, which is sufficient to protect mice from nonhomologous IAV challenge. Thus, a current vaccine strategy, Flumist, may serve as a priming platform for the rapid induction of large numbers of memory CD8 T cells with the capacity for broad protection against influenza.

Influenza Vaccines - administration & dosage

Humans

Cross Reactions - immunology

Lymphocyte Activation - immunology

Animals

Influenza Vaccines - immunology

Time Factors

CD8-Positive T-Lymphocytes - virology

CD8-Positive T-Lymphocytes - metabolism

Influenza Vaccines - therapeutic use

Female

Immunologic Memory

Influenza A virus - immunology

Influenza, Human - virology

Mice

Mice, Inbred BALB C

CD8-Positive T-Lymphocytes - immunology

Influenza, Human - prevention & control

Influenza, Human - immunology

Details

Title: Subtitle: Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine
Creators: Bram Slütter - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Lecia L Pewe
Peter Lauer
John T Harty
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.190(8), pp.3854-3858
DOI: 10.4049/jimmunol.1202790
PMID: 23467935
PMCID: PMC3622175
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Publisher: United States
Grant note: AI085515 / NIAID NIH HHS R37 AI042767 / NIAID NIH HHS R01 AI095178 / NIAID NIH HHS AI100527 / NIAID NIH HHS R01 AI100527 / NIAID NIH HHS AI95178 / NIAID NIH HHS AI96850 / NIAID NIH HHS AI42767 / NIAID NIH HHS R01 AI042767 / NIAID NIH HHS R01 AI085515 / NIAID NIH HHS R21 AI042767 / NIAID NIH HHS R21 AI096850 / NIAID NIH HHS
Language: English
Date published: 04/15/2013
Academic Unit: Pathology
Record Identifier: 9984046907302771

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