Journal article
Cyanidin-3-Glucoside Ameliorates Ethanol Neurotoxicity in the Developing Brain
Journal of neuroscience research, Vol.89(10), pp.1676-1684
10/2011
DOI: 10.1002/jnr.22689
PMCID: PMC3154369
PMID: 21671257
Abstract
Ethanol exposure induces neurodegeneration in the developing central nervous system (CNS). Fetal Alcohol Spectrum Disorders (FASD) are caused by ethanol exposure during pregnancy and are the most common nonhereditary cause of mental retardation. It is important to identify agents that provide neuroprotection against ethanol neurotoxicity. Multiple mechanisms have been proposed for ethanol-induced neurodegeneration, and oxidative stress is one of the most important mechanisms. Recent evidence indicates that glycogen synthase kinase 3β (GSK3β) is a potential mediator of ethanol-mediated neuronal death (
Luo, 2009
). Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is a potent natural antioxidant. Our previous study suggested that C3G inhibited GSK3β activity in neurons (
Chen et al., 2009
). Using a third trimester equivalent mouse model of ethanol exposure, we tested the hypothesis that C3G can ameliorate ethanol-induced neuronal death in the developing brain. Intraperitoneal injection of C3G reduced ethanol-meditated caspase-3 activation, neurodegeneration and microglial activation in the cerebral cortex of seven-day-old mice. C3G blocked ethanol-mediated GSK3β activation by inducing the phosphorylation at serine 9 while reducing the phosphorylation at tyrosine 216. C3G also inhibited ethanol-stimulated expression of malondialdehyde (MDA) and p47phox, indicating that C3G alleviated ethanol-induced oxidative stress. These results provide important insight into the therapeutic potential of C3G.
Details
- Title: Subtitle
- Cyanidin-3-Glucoside Ameliorates Ethanol Neurotoxicity in the Developing Brain
- Creators
- Zunji Ke - University of KentuckyYing Liu - Chinese Academy of SciencesXin Wang - University of KentuckyZhiqin Fan - Chinese Academy of SciencesGang Chen - University of KentuckyMei Xu - University of KentuckyKimberley A Bower - University of KentuckyJacqueline A Frank - University of KentuckyXiaoming Ou - University of Mississippi Medical CenterXianglin Shi - University of KentuckyJia Luo - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- Journal of neuroscience research, Vol.89(10), pp.1676-1684
- DOI
- 10.1002/jnr.22689
- PMID
- 21671257
- PMCID
- PMC3154369
- NLM abbreviation
- J Neurosci Res
- ISSN
- 0360-4012
- eISSN
- 1097-4547
- Grant note
- R01 AA015407-06 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA
- Language
- English
- Date published
- 10/2011
- Academic Unit
- Pathology
- Record Identifier
- 9984201123502771
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