Journal article
Cyclo(L-alanyl-L-seryl).H2O and cyclo(glycyl-L-seryl)
Acta crystallographica. Section C, Crystal structure communications, Vol.52(2), pp.383-387
02/15/1996
DOI: 10.1107/S0108270195012248
Abstract
We have determined the crystal structures of two diketopiperazines, cyclo(L-alanyl-L-seryl).H2O (cis-6-hydroxymethyl-3-methyl-2,5-piperazinedione hydrate, C6H10N2C3.H2O) and cyclo(glycyl-L-seryl) (3-hydroxymethyl-2,5-piperazinedione, C5H8N2O3). The crystal structure of cyclo(L-alanyl-L-seryl).H2O [cyclo(L-Ala-L-Ser)] consists of a peptide backbone that is hydrogen bonded to two adjacent diketopiperazine rings, forming extended chains through the crystal. The serine hydroxy group of cyclo(L-Ala-L-Ser) is hydrated by two adjacent water molecules in the crystal. In contrast, the crystal structure of cyclo(glycyl-L-seryl) [cyclo(Gly-L-Ser)] is held together by a three-dimensional network of hydrogen bonds. The serine hydroxy group of cyclo(Gly-L-Ser) participates in two hydrogen bonds with the peptide backbone of neighboring molecules.
Details
- Title: Subtitle
- Cyclo(L-alanyl-L-seryl).H2O and cyclo(glycyl-L-seryl)
- Creators
- Dale C Swenson - University of IowaSusan M Habermann - Univ. Iowa, dep. chemistry, Iowa City IA 52242, United StatesKenneth P Murphy - Univ. Iowa, dep. chemistry, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Acta crystallographica. Section C, Crystal structure communications, Vol.52(2), pp.383-387
- DOI
- 10.1107/S0108270195012248
- ISSN
- 0108-2701
- eISSN
- 1600-5759
- Publisher
- Blackwell
- Language
- English
- Date published
- 02/15/1996
- Academic Unit
- Chemistry
- Record Identifier
- 9984622044002771
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