Journal article
Cyclooxygenase-2 Expression in Pediatric Sarcomas
Pediatric and developmental pathology, Vol.5(4), pp.356-364
07/2002
DOI: 10.1007/s10024-002-0005-1
PMID: 12024286
Abstract
Therapies for metastatic pediatric sarcomas have reached maximum tolerated doses, but continue to provide suboptimal cure rates. Additionally, these treatments are associated with numerous short- and long-term side effects. Therefore, the search for newer, less toxic therapeutic agents is warranted. Overexpression of the inducible enzyme, cyclooxygenase-2 (COX-2), has been discovered in a variety of adult solid tumors and numerous studies have shown COX-2 inhibitors to have significant antiproliferative effects. Therefore, we sought to determine the expression of COX-2 in pediatric sarcomas. We evaluated rhabdomyosarcoma (RMS), osteosarcoma (OS), and Ewing sarcoma (EWS) samples for COX-2 expression by immunohistochemical analysis as well as by cDNA microarray analysis. COX-2 expression was detected in 48/58 (82.8%) tumors by immunohistochemistry and in an additional 52/59 (88.1%) tumors tested by microarray gene analysis. There was a trend toward increased COX-2 expression in metastatic rhabdomyosarcoma and osteosarcoma, though it did not reach clinical significance. The degree of COX-2 immunoreactivity did not vary significantly with other clinicopathologic features such as age, gender, or histologic classification. We conclude that the majority of these pediatric sarcoma samples express COX-2 to varying degrees. Therefore, studies testing the efficacy of COX-2 inhibitors in the treatment of pediatric sarcomas are warranted.
Details
- Title: Subtitle
- Cyclooxygenase-2 Expression in Pediatric Sarcomas
- Creators
- David S Dickens - Department of Pediatrics, Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USARafal Kozielski - Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USAJaved Khan - Pediatric Oncology Branch, National Cancer Institute, Gaithersburg, MD 20877, USAAnne Forus - Department of Tumor Biology, Norwegian Radium Hospital, Montebello, N0310 Oslo, NorwayTimothy P Cripe - Department of Pediatrics, Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
- Resource Type
- Journal article
- Publication Details
- Pediatric and developmental pathology, Vol.5(4), pp.356-364
- DOI
- 10.1007/s10024-002-0005-1
- PMID
- 12024286
- ISSN
- 1093-5266
- eISSN
- 1615-5742
- Language
- English
- Date published
- 07/2002
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093338402771
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