Journal article
Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma
Journal of pediatric hematology/oncology, Vol.25(4), pp.282-285
2003
DOI: 10.1097/00043426-200304000-00003
PMID: 12679640
Abstract
Purpose: To determine if expression of cyclooxygenase (COX)-2, an inducible enzyme with known tumor-promoting activity, correlates with outcome in pediatric sarcomas. COX-2 overexpression correlates with more aggressive disease in a variety of adult solid tumors.
Methods: Archived human osteosarcoma, rhabdomyosarcoma, and Ewing sarcoma tumors were retrospectively evaluated, blinded to outcome, for COX-2 expression by immunohistochemistry and correlated with patient characteristics and survival.
Results: COX-2 expression was detected in 94 of 142 (66%) tumors (osteosarcoma, 66/99 [67%]; rhabdomyosarcoma, 21/35 [60%]; Ewing sarcoma, 7/8 [88%]) and 51 of 85 (60%) diagnostic biopsies (osteosarcoma, 26/45 [58%]; rhabdomyosarcoma, 21/35 [60%]; Ewing sarcoma, 4/5 [80%]). COX-2 expression did not vary with clinicopathologic features and was not predictive of prognosis in these cases.
Conclusions: This study does not support the use of COX-2 expression as an upfront prognostic variable in patients with osteosarcoma or rhabdomyosarcoma. Results from the small number of patients studied with Ewing sarcoma suggest a similar lack of predictive value for COX-2 expression. However, COX-2 inhibitors are not entirely dependent upon enzyme expression for their antitumor effects; this study does not necessarily preclude the use of COX-2 inhibitors for the treatment of pediatric sarcomas.
Details
- Title: Subtitle
- Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma
- Creators
- David S DICKENS - Division of Hematology/Oncology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United StatesRafal KOZIELSKI - Division of Pathology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United StatesPatrick J LEAVEY - Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United StatesCharles TIMMONS - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United StatesTimothy P CRIPE - Division of Hematology/Oncology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric hematology/oncology, Vol.25(4), pp.282-285
- Publisher
- Lippincott
- DOI
- 10.1097/00043426-200304000-00003
- PMID
- 12679640
- ISSN
- 1077-4114
- eISSN
- 1536-3678
- Language
- English
- Date published
- 2003
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093317402771
Metrics
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