Journal article
Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans
American journal of physiology. Heart and circulatory physiology, Vol.302(12), pp.H2629-H2634
06/15/2012
DOI: 10.1152/ajpheart.00032.2012
PMCID: PMC3378267
PMID: 22505642
Abstract
The augmentation index and central blood pressure increase with normal aging. Recently, cyclooxygenase (COX) inhibitors, commonly used for the treatment of pain, have been associated with transient increases in the risk of cardiovascular events. We examined the effects of the COX inhibitor indomethacin (Indo) on central arterial hemodynamics and wave reflection characteristics in young and old healthy adults. High-fidelity radial arterial pressure waveforms were measured noninvasively by applanation tonometry before (control) and after Indo treatment in young (25 ± 5 yr, 7 men and 6 women) and old (64 ± 6 yr, 5 men and 6 women) subjects. Aortic systolic (control: 115 ± 3 mmHg vs. Indo: 125 ± 5 mmHg,
P
< 0.05) and diastolic (control: 74 ± 2 mmHg vs. Indo: 79 ± 3 mmHg,
P
< 0.05) pressures were elevated after Indo treatment in older subjects, whereas only diastolic pressure was elevated in young subjects (control: 71 ± 2 mmHg vs. Indo: 76 ± 1 mmHg,
P
< 0.05). Mean arterial pressure increased in both young and old adults after Indo treatment (
P
< 0.05). The aortic augmentation index and augmented pressure were elevated after Indo treatment in older subjects (control: 30 ± 5% vs. Indo 36 ± 6% and control 12 ± 1 mmHg vs. Indo: 18 ± 2 mmHg, respectively,
P
< 0.05), whereas pulse pressure amplification decreased (change: 8 ± 3%,
P
< 0.05). In addition, older subjects had a 61 ± 11% increase in wasted left ventricular energy after Indo treatment (
P
< 0.05). In contrast, young subjects showed no significant changes in any of the variables of interest. Taken together, these results demonstrate that COX inhibition with Indo unfavorably increases central wave reflection and augments aortic pressure in old but not young subjects. Our results suggest that aging individuals have a limited ability to compensate for the acute hemodynamic changes caused by systemic COX inhibition.
Details
- Title: Subtitle
- Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans
- Creators
- Jill N Barnes - Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; andDarren P Casey - Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; andCasey N Hines - Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; andWayne T Nicholson - Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; andMichael J Joyner - Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota; and
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.302(12), pp.H2629-H2634
- Publisher
- American Physiological Society; Bethesda, MD
- DOI
- 10.1152/ajpheart.00032.2012
- PMID
- 22505642
- PMCID
- PMC3378267
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Grant note
- RR-024150; AG-16574-11 PP2; AR-056950; AG-38067; HL-105467; HL-46493 / National Institutes of Health
- Language
- English
- Date published
- 06/15/2012
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984047996502771
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