Journal article
Cyclophilins: a new family of proteins involved in intracellular folding
Trends in Cell Biology, Vol.2(9), pp.272-276
1992
DOI: 10.1016/0962-8924(92)90200-7
PMID: 14731520
Abstract
Proteins of the cyclophilin family display two intriguing properties. On the one hand, they are the intracellular receptors for the immunosuppressive drug cyclosporin A (CsA); on the other hand, they function in vitro as enzymes that catalyse slow steps in protein folding. A dissection of the role of CsA in mediating immunosuppression, together with recent studies on the biology of cyclophilins in the absence of this ligand, is providing fundamental insight into the cellular function of this protein family.
Details
- Title: Subtitle
- Cyclophilins: a new family of proteins involved in intracellular folding
- Creators
- Mark A. Stamnes - Howard Hughes Medical InstituteSuzanne L. Rutherford - Howard Hughes Medical InstituteCharles S. Zuker - Howard Hughes Medical Institute
- Resource Type
- Journal article
- Publication Details
- Trends in Cell Biology, Vol.2(9), pp.272-276
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/0962-8924(92)90200-7
- PMID
- 14731520
- ISSN
- 0962-8924
- eISSN
- 1879-3088
- Language
- English
- Date published
- 1992
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984297512002771
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