Journal article
Cyclophosphamide, Vincristine, and Prednisone Followed by Tositumomab and Iodine-131–Tositumomab in Patients With Untreated Low-Grade Follicular Lymphoma: Eight-Year Follow-Up of a Multicenter Phase II Study
Journal of clinical oncology, Vol.28(18), pp.3035-3041
06/20/2010
DOI: 10.1200/JCO.2009.27.8325
PMID: 20458031
Abstract
Purpose The efficacy and safety of cyclophosphamide, vincristine, and prednisone (CVP) followed by tositumomab and iodine-131 (131I) –tositumomab therapy were evaluated in a multicenter phase II study in patients with untreated low-grade follicular lymphoma. Patients and Methods Patients received six cycles of CVP followed by one cycle of tositumomab and 131I-tositumomab (one dosimetric dose and one therapeutic dose). The treatment was evaluated for efficacy and safety. Results All 30 patients enrolled completed CVP as well as tositumomab and 131I-tositumomab therapy. The overall response rate after completion of therapy was 100%, with 28 patients (93%) achieving a complete response (CR) and two patients achieving a partial response. Of the 17 patients with bone marrow involvement at enrollment, 15 achieved a confirmed CR. Fourteen of 15 patients with bulky disease (≥ 5 cm) had a CR after treatment completion. After a median follow-up of 8.4 years, the median response duration had not been reached (range, 3 to 111+ months). Five-year progression-free and overall survival rates were 56% and 83%, respectively. The most common grade ≥ 3 hematologic adverse events were neutropenia (87%) and thrombocytopenia (37%). Nineteen patients received growth factor support, and three required blood product transfusions. No patients developed human antimurine antibodies. Two patients developed myelodysplastic syndrome/acute myeloid leukemia. Conclusion These mature data demonstrate that sequential therapy with a non-anthracycline–containing regimen comprising CVP followed by one cycle of tositumomab and 131I-tositumomab produced high response rates with adequate safety and durable remissions and that this regimen represents a highly active treatment for first-line therapy of follicular non-Hodgkin's lymphoma.
Details
- Title: Subtitle
- Cyclophosphamide, Vincristine, and Prednisone Followed by Tositumomab and Iodine-131–Tositumomab in Patients With Untreated Low-Grade Follicular Lymphoma: Eight-Year Follow-Up of a Multicenter Phase II Study
- Creators
- Brian K Link - From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MIPeter Martin - From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MIMark S Kaminski - From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MIStanley J Goldsmith - From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MIMorton Coleman - From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MIJohn P Leonard - From the University of Iowa Hospitals and Clinics, Iowa City, IA; Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY; and University of Michigan Comprehensive Cancer Center, Ann Arbor, MI
- Resource Type
- Journal article
- Publication Details
- Journal of clinical oncology, Vol.28(18), pp.3035-3041
- DOI
- 10.1200/JCO.2009.27.8325
- PMID
- 20458031
- ISSN
- 0732-183X
- eISSN
- 1527-7755
- Language
- English
- Date published
- 06/20/2010
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094503702771
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