Cyclotron production and radiochemical separation of Co-55 and Co-58m from Fe-54, Ni-58 and Fe-57 targets

H. F. Valdovinos; R. Hernandez; S. Graves; P. A. Ellison; T. E. Barnhart; C. P. Theuer; J. W. Engle; W. Cai; R. J. Nickles

doi:10.1016/j.apradiso.2017.09.005

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Cyclotron production and radiochemical separation of Co-55 and Co-58m from Fe-54, Ni-58 and Fe-57 targets

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Cyclotron production and radiochemical separation of Co-55 and Co-58m from Fe-54, Ni-58 and Fe-57 targets

H. F. Valdovinos, R. Hernandez, S. Graves, P. A. Ellison, T. E. Barnhart, C. P. Theuer, J. W. Engle, W. Cai and R. J. Nickles

Applied radiation and isotopes, Vol.130, pp.90-101

12/01/2017

DOI: 10.1016/j.apradiso.2017.09.005

PMCID: PMC5673506

PMID: 28946101

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Abstract

This work presents the production with a cyclotron of the positron emitter Co-55 via the Fe-54(d,n) and Ni-58(p,alpha) reactions and the Auger electron emitter Co-55m via the Fe-57(d,n) reaction after high current (40 mu A p and 60 mu A d) irradiation on electroplated targets. High specific activity radionuclides (up to 55.6 GBq/mu mol Co-55 and 31.8 GBq/mu mol Co-55m) with high radionuclidic purity (99.995% Co-55 from Fe-54, 98.8% Co-55 from Ni-58, and 98.7% Co-55m from Fe-57 at end of bombardment, EoB), in high activity concentration (final separated radionuclide in < 0.6 mL) and with almost quantitative overall activity separation yield (> 92%) were obtained after processing of the irradiated targets with novel radiochemical separation methods based on HCl dissolution and the resin N,N,N',N'-tetrakis-2-ethylhexyldiglycolamide (DGA, branched). One hour long irradiations using 38-65, 110-214 and 59-78 mg of enriched Fe-54 (99;93%), Ni-58 (99.48%) and Fe-57 (95.06%), respectively, electroplated over a 1.0 cm(2) surface, yielded 58(2) +/- 66 MBq Co-55, 372 +/- 14 MBq Co-55 and 810 +/- 186 MBq Co-55m, respectively, decay corrected to EoB. The separation methods allow for the recovery of the costly enriched target materials, which were reconstituted into metallic targets after novel electroplating methods, with an overall recycling efficiency of 93 +/- 4% for iron. The produced radionuclides were used to radiolabel the angiogenesis marker antibody TRC105 conjugated to the chelator NOTA as a demonstration of their quality.

Chemistry

Chemistry, Inorganic & Nuclear

Life Sciences & Biomedicine

Nuclear Science & Technology

Physical Sciences

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Technology

Details

Title: Subtitle: Cyclotron production and radiochemical separation of Co-55 and Co-58m from Fe-54, Ni-58 and Fe-57 targets
Creators: H. F. Valdovinos - University of Wisconsin–Madison
R. Hernandez - Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA
S. Graves - University of Wisconsin–Madison
P. A. Ellison - University of Wisconsin–Madison
T. E. Barnhart - University of Wisconsin–Madison
C. P. Theuer - Tracon Pharmaceuticals
J. W. Engle - University of Wisconsin–Madison
W. Cai - University of Wisconsin–Madison
R. J. Nickles - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Applied radiation and isotopes, Vol.130, pp.90-101
Publisher: Elsevier
DOI: 10.1016/j.apradiso.2017.09.005
PMID: 28946101
PMCID: PMC5673506
ISSN: 0969-8043
eISSN: 1872-9800
Number of pages: 12
Grant note: DOESC0008384 / Department of Energy; United States Department of Energy (DOE) P30CA014520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Science and Medicine Graduate Research Scholars (SciMed GRS) Program at UW-Madison
Language: English
Date published: 12/01/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383295902771

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