Journal article
Cystatin C Is Associated with the Extent and Characteristics of Coronary Atherosclerosis in Patients with Preserved Renal Function
Folia biologica, Vol.62(6), pp.225-234
2016
PMID: 28189145
Abstract
Cystatin C (CysC), an endogenous inhibitor of cysteine proteases and a sensitive and accurate marker of renal function, is associated with the severity of coronary atherosclerosis assessed by angiography and future cardiovascular events according to previous studies. We aimed to evaluate the association between CysC levels and coronary plaque volume, composition and phenotype assessed by intravascular ultrasound and intravascular ultrasound-derived virtual histology in patients with preserved renal function. Forty-four patients with angiographically documented coronary artery disease and complete intravascular imaging were included in the study. Patients were categorized into tertiles by CysC levels. Subjects in the high CysC tertile had significantly higher mean plaque burden (48.0 % ± 6.9 vs. 42.8 % ± 7.4, P = 0.029), lower mean lumen area (8.1 mm2 ± 1.7 vs. 9.9 mm2 ± 3.1, P = 0.044) and a higher number of 5-mm vessel segments with minimum lumen area < 4 mm2 (17.9 ± 18.9 vs. 6.8 ± 11.7, P = 0.021) compared to patients in the lower tertiles. In addition, CysC levels demonstrated significant positive correlation with the mean plaque burden (r = 0.35, P = 0.021). Neither relative, nor absolute plaque components differed significantly according to CysC tertiles. The Liverpool Active Plaque Score was significantly higher in the high CysC tertile patients (0.91 ± 1.0 vs. 0.18 ± 0.92, P = 0.02). In conclusion, our study demonstrated a significant association of increased CysC levels with more advanced coronary artery disease and higher risk plaque phenotype in patients with preserved renal function.
Details
- Title: Subtitle
- Cystatin C Is Associated with the Extent and Characteristics of Coronary Atherosclerosis in Patients with Preserved Renal Function
- Creators
- A Král - General University Hospital in PragueT Kovárník - General University Hospital in PragueZ Vaníčková - General University Hospital in PragueH Skalická - General University Hospital in PragueJ Horák - General University Hospital in PragueK Bayerová - General University Hospital in PragueZ Chen - University of IowaA Wahle - University of IowaK Kopřiva - Cardiology Department of Homolka Hospital, Prague, Czech RepublicL Zhang - University of IowaH Benáková - General University Hospital in PragueM Sonka - University of IowaA Linhart - General University Hospital in Prague
- Resource Type
- Journal article
- Publication Details
- Folia biologica, Vol.62(6), pp.225-234
- PMID
- 28189145
- NLM abbreviation
- Folia Biol (Praha)
- ISSN
- 0015-5500
- eISSN
- 2533-7602
- Language
- English
- Date published
- 2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186689402771
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