Cystatin C Is Associated with the Extent and Characteristics of Coronary Atherosclerosis in Patients with Preserved Renal Function

A Král; T Kovárník; Z Vaníčková; H Skalická; J Horák; K Bayerová; Z Chen; A Wahle; K Kopřiva; L Zhang; H Benáková; M Sonka; A Linhart

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Cystatin C Is Associated with the Extent and Characteristics of Coronary Atherosclerosis in Patients with Preserved Renal Function

Journal article

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Cystatin C Is Associated with the Extent and Characteristics of Coronary Atherosclerosis in Patients with Preserved Renal Function

A Král, T Kovárník, Z Vaníčková, H Skalická, J Horák, K Bayerová, Z Chen, A Wahle, K Kopřiva, L Zhang, …

Folia biologica, Vol.62(6), pp.225-234

2016

PMID: 28189145

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Abstract

Cystatin C (CysC), an endogenous inhibitor of cysteine proteases and a sensitive and accurate marker of renal function, is associated with the severity of coronary atherosclerosis assessed by angiography and future cardiovascular events according to previous studies. We aimed to evaluate the association between CysC levels and coronary plaque volume, composition and phenotype assessed by intravascular ultrasound and intravascular ultrasound-derived virtual histology in patients with preserved renal function. Forty-four patients with angiographically documented coronary artery disease and complete intravascular imaging were included in the study. Patients were categorized into tertiles by CysC levels. Subjects in the high CysC tertile had significantly higher mean plaque burden (48.0 % ± 6.9 vs. 42.8 % ± 7.4, P = 0.029), lower mean lumen area (8.1 mm2 ± 1.7 vs. 9.9 mm2 ± 3.1, P = 0.044) and a higher number of 5-mm vessel segments with minimum lumen area < 4 mm2 (17.9 ± 18.9 vs. 6.8 ± 11.7, P = 0.021) compared to patients in the lower tertiles. In addition, CysC levels demonstrated significant positive correlation with the mean plaque burden (r = 0.35, P = 0.021). Neither relative, nor absolute plaque components differed significantly according to CysC tertiles. The Liverpool Active Plaque Score was significantly higher in the high CysC tertile patients (0.91 ± 1.0 vs. 0.18 ± 0.92, P = 0.02). In conclusion, our study demonstrated a significant association of increased CysC levels with more advanced coronary artery disease and higher risk plaque phenotype in patients with preserved renal function.

Phenotype

Biomarkers - metabolism

Coronary Artery Disease - metabolism

Coronary Artery Disease - physiopathology

Cystatin C - metabolism

Female

Glomerular Filtration Rate

Humans

Inflammation - pathology

Kidney - metabolism

Kidney - physiopathology

Kidney Function Tests

Male

Middle Aged

Plaque, Atherosclerotic - metabolism

Plaque, Atherosclerotic - physiopathology

Tumor Necrosis Factor-alpha - metabolism

Vascular Cell Adhesion Molecule-1 - metabolism

Details

Title: Subtitle: Cystatin C Is Associated with the Extent and Characteristics of Coronary Atherosclerosis in Patients with Preserved Renal Function
Creators: A Král - General University Hospital in Prague
T Kovárník - General University Hospital in Prague
Z Vaníčková - General University Hospital in Prague
H Skalická - General University Hospital in Prague
J Horák - General University Hospital in Prague
K Bayerová - General University Hospital in Prague
Z Chen - University of Iowa
A Wahle - University of Iowa
K Kopřiva - Cardiology Department of Homolka Hospital, Prague, Czech Republic
L Zhang - University of Iowa
H Benáková - General University Hospital in Prague
M Sonka - University of Iowa
A Linhart - General University Hospital in Prague
Resource Type: Journal article
Publication Details: Folia biologica, Vol.62(6), pp.225-234
PMID: 28189145
NLM abbreviation: Folia Biol (Praha)
ISSN: 0015-5500
eISSN: 2533-7602
Language: English
Date published: 2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; The Iowa Institute for Biomedical Imaging; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9984186689402771

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