Journal article
Cystic fibrosis problem probed by proteolysis
Nature structural biology, Vol.5(3), pp.167-169
03/1998
DOI: 10.1038/nsb0398-167
PMID: 9501902
Abstract
The cystic fibrosis mutation, ΔF508, disrupts CFTR biosynthesis. ΔF508 protein resembles an early intermediate in wild type folding, but fails to adopt a mature conformation and hence cannot escape the ER.
Details
- Title: Subtitle
- Cystic fibrosis problem probed by proteolysis
- Creators
- Michael J WelshLynda S Ostedgaard
- Resource Type
- Journal article
- Publication Details
- Nature structural biology, Vol.5(3), pp.167-169
- DOI
- 10.1038/nsb0398-167
- PMID
- 9501902
- ISSN
- 1072-8368
- eISSN
- 2331-365X
- Language
- English
- Date published
- 03/1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984094746502771
Metrics
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