Cystic fibrosis related diabetes: Medical management

Katie Larson Ode; Christine L. Chan; Andrea Granados; Amir Moheet; Antoinette Moran; Amanda L. Brennan

doi:10.1016/j.jcf.2019.08.003

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Cystic fibrosis related diabetes: Medical management

Journal article

Open access

Peer reviewed

Cystic fibrosis related diabetes: Medical management

Katie Larson Ode, Christine L. Chan, Andrea Granados, Amir Moheet, Antoinette Moran and Amanda L. Brennan

Journal of cystic fibrosis, Vol.18, pp.S10-S18

10/01/2019

DOI: 10.1016/j.jcf.2019.08.003

PMID: 31679720

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Abstract

Cystic Fibrosis Related Diabetes Mellitus (CFRD) drives excess pulmonary morbidity and mortality in patients with cystic fibrosis (CF). The recommended treatment is insulin therapy. Insulin therapy in CF should be customized to the specific patient. CF patients typically require intensive insulin regimens such as multiple daily injections or insulin pump therapy, but frequently require lower doses than in type 1 diabetes mellitus. Patients with CF may also need insulin to cover intravenous or enteral feedings. Pre-diabetic glycaemic abnormalities are also associated with clinical decline in cystic fibrosis prior to the diagnosis of CFRD, however, whether and how this should be treated is not fully determined. There is also interest, but inadequate data regarding other treatments besides insulin (i.e., oral medications) for treatment of pre-diabetes or CFRD. CFTR potentiator and corrector therapy has yet to demonstrate an effect on the rate of CFRD, but may improve insulin secretion. There is great opportunity for further research to better understand when and how best to treat glycaemic abnormalities in cystic fibrosis. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.

Respiratory System

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Cystic fibrosis related diabetes: Medical management
Creators: Katie Larson Ode - University of Iowa
Christine L. Chan - Children's Hospital Colorado
Andrea Granados - Washington University in St. Louis
Amir Moheet - University of Minnesota
Antoinette Moran - University of Minnesota
Amanda L. Brennan - Wythenshawe Hospital
Resource Type: Journal article
Publication Details: Journal of cystic fibrosis, Vol.18, pp.S10-S18
DOI: 10.1016/j.jcf.2019.08.003
PMID: 31679720
NLM abbreviation: J Cyst Fibros
ISSN: 1569-1993
eISSN: 1873-5010
Publisher: Elsevier
Number of pages: 9
Grant note: Cystic Fibrosis Foundation, Emerging Leaders in CF Endocrinology (EnVision) Program
Language: English
Date published: 10/01/2019
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics
Record Identifier: 9984354505302771

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