Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit

John M Dagle; Tyler J Fisher; Susan E Haynes; Susan K Berends; Patrick D Brophy; Frank H Morriss; Jeffrey C Murray

doi:10.1016/j.jpeds.2011.01.002

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Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit

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Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit

John M Dagle, Tyler J Fisher, Susan E Haynes, Susan K Berends, Patrick D Brophy, Frank H Morriss and Jeffrey C Murray

The Journal of pediatrics, Vol.159(1), pp.104-109

07/2011

DOI: 10.1016/j.jpeds.2011.01.002

PMCID: PMC3115515

PMID: 21353244

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https://www.ncbi.nlm.nih.gov/pmc/articles/3115515View

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Abstract

To determine genetic and clinical risk factors associated with elevated systolic blood pressure (ESBP) in preterm infants after discharge from the neonatal intensive care unit (NICU). A convenience cohort of infants born at <32 weeks gestational age was followed after NICU discharge. We retrospectively identified a subgroup of subjects with ESBP (systolic blood pressure [SBP] >90th percentile for term infants). Genetic testing identified alleles associated with ESBP. Multivariate logistic regression analysis was performed for the outcome ESBP, with clinical characteristics and genotype as independent variables. Predictors of ESBP were cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) (rs28360521) CC genotype (OR, 2.92; 95% CI, 1.48-5.79), adjusted for outpatient oxygen therapy (OR, 4.53; 95% CI, 2.23-8.81) and history of urinary tract infection (OR, 4.68; 95% CI, 1.47-14.86). Maximum SBP was modeled by multivariate linear regression analysis: maximum SBP = 84.8 mm Hg + 6.8 mm Hg if cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) CC genotype + 6.8 mm Hg if discharged on supplemental oxygen + 4.4 mm Hg if received inpatient glucocorticoids (P = .0002). ESBP is common in preterm infants with residual lung disease after discharge from the NICU. This study defines clinical factors associated with ESBP, identifies a candidate gene for further testing, and supports the recommendation to monitor blood pressure before age 3 years, as is suggested for term infants.

SBP

TFAP2B

SNP

CYP2D6

BPD

NICU

UTI

ESBP

Details

Title: Subtitle: Cytochrome P450 (CYP2D6) Genotype is Associated with Elevated Systolic Blood Pressure in Preterm Infants after Discharge from the Neonatal Intensive Care Unit
Creators: John M Dagle - Department of Pediatrics, University of Iowa, Iowa City, IA
Tyler J Fisher - Carver College of Medicine, University of Iowa, Iowa City, IA
Susan E Haynes - Department of Pediatrics, University of Iowa, Iowa City, IA
Susan K Berends - Department of Pediatrics, University of Iowa, Iowa City, IA
Patrick D Brophy - Department of Pediatrics, University of Iowa, Iowa City, IA
Frank H Morriss - Department of Pediatrics, University of Iowa, Iowa City, IA
Jeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.159(1), pp.104-109
DOI: 10.1016/j.jpeds.2011.01.002
PMID: 21353244
PMCID: PMC3115515
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Publisher: Elsevier Inc
Grant note: R01 HD052953, R01 HD57192, P30 ES05605, and K08 DK064333 / National Institutes of Health FY2006-575 and FY2008-260 / March of Dimes
Language: English
Date published: 07/2011
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9984025262702771

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