Journal article
Cytogenetics of Swarm Rat Chondrosarcoma
The Iowa orthopaedic journal, Vol.25, pp.135-140
2005
PMCID: PMC1888785
PMID: 16089086
Appears in Diamond Open Access
Abstract
The Swarm rat chondrosarcoma is a tumor tissue line derived from a tumor that arose spontaneously in a Sprague-Dawley rat. The original tissue has given rise to several tissue lines and cell lines that have been prepared in different laboratories. It has been observed that these lines differed in their growth rates and biochemical characteristics. We have characterized our Swarm rat chondrosarcoma tissue and cell lines currently in use in terms of their cytogenetic profiles and their tumorigenic properties in vivo. We found a wide variety of chromosomal abnormalities among cell lines, including translocations, deletions and polyploidy. There were also significant differences in their growth properties in vivo, giving rise to tumors of a few milligrams in the case of Ng cells, to 35 grams in the tissue line JWS. The cytogenetic complexity of the Swarm rat chondrosarcoma between and among different lines makes it very suitable to address questions about the changes that occur as a result of karyotypic abnormalities and to provide links between cytogenetic abnormalities and the dynamic oncogenic machinery.
Details
- Title: Subtitle
- Cytogenetics of Swarm Rat Chondrosarcoma
- Creators
- Jeff W Stevens - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IowaShivanand R Patil - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IowaDiane K Jordan - Cytogenetics Laboratory, OSF St. Francis Medical Center, Peoria, IllinoisJames H Kimura - Department of Surgery, John A. Burns School of Medicine, Honolulu, HawaiiJose A Morcuende - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Iowa orthopaedic journal, Vol.25, pp.135-140
- Publisher
- Dept. of Orthopaedics, The University of Iowa; United States
- PMID
- 16089086
- PMCID
- PMC1888785
- ISSN
- 1541-5457
- eISSN
- 1555-1377
- Language
- English
- Date published
- 2005
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Orthopedics and Rehabilitation
- Record Identifier
- 9984040370402771
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