Journal article
Cytokine Registry In Stroke Patients (CRISP): Protocol of a prospective observational study
Medicine (Baltimore), Vol.99(28), pp.e20921-e20921
07/10/2020
DOI: 10.1097/MD.0000000000020921
PMCID: PMC7360230
PMID: 32664088
Abstract
Inflammation is an important pathophysiological process after an acute stroke (AS). Pro- and anti-inflammatory molecules (cytokines and interleukins) are the key players during this mechanism. Emerging evidence indicate that these molecules can serve as biomarkers of stroke progression and outcome and as novel therapeutics agents. The aim of this study is to explore the temporal changes in these molecules and validate them as biomarker of AS progression and neurological outcome.
The “Cytokine Registry In Stroke Patients (CRISP)” is a prospective cohort study of 600 AS patients presenting to the tertiary hospital with-in 24 h of the onset of symptoms. Plasma cytokines and interleukins will be collected at admission and 24 h after and will be measured using enzyme-linked immunosorbent assay (ELISA) to evaluate the difference in their variation among different gender, race and ethnicity and their association with various neurological outcomes. The primary exposures are biological sex (male, female) and race/ethnicity. Confounding variables include age, vascular risk factors, infarct size, stroke onset to presentation time, and identified stroke etiologies. Matched controls will be used for the comparison and evaluation of the difference among gender and race/ethnicities.
CRISP is a prospective observational study that investigates the role and relationship of molecular biomarkers identifying specific and relevant targets pertinent for monitoring the progression and outcome in AS patients.
Trial Registration: The study is registered on ClinicalTrial.gov:
https://clinicaltrials.gov/
(NCT03297827).
Details
- Title: Subtitle
- Cytokine Registry In Stroke Patients (CRISP): Protocol of a prospective observational study
- Creators
- Mudassir Farooqui - Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NMAsad Ikram - Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NMSajid Suriya - Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NMSantiago Ortega-Gutierrez - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IASidra Saleem - Department of Neurology, University of Toledo, Toledo, OHEnrique Leira - Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IASyed A Quadri - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MAMyranda Robinson - Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NMFares Qeadan - Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USASurojit Paul - Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NMAtif Zafar - Department of Neurology, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM
- Resource Type
- Journal article
- Publication Details
- Medicine (Baltimore), Vol.99(28), pp.e20921-e20921
- DOI
- 10.1097/MD.0000000000020921
- PMID
- 32664088
- PMCID
- PMC7360230
- NLM abbreviation
- Medicine (Baltimore)
- ISSN
- 0025-7974
- eISSN
- 1536-5964
- Publisher
- Wolters Kluwer Health
- Grant note
- GR07332 / Mountain West Clinical and Translational Research Infrastructure Network
- Language
- English
- Date published
- 07/10/2020
- Academic Unit
- Neurology; Radiology; Epidemiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984070518902771
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