Journal article
Cytokine-mediated regulation of antimicrobial proteins
Nature reviews. Immunology, Vol.8(11), pp.829-835
11/2008
DOI: 10.1038/nri2433
PMCID: PMC2901862
PMID: 18949018
Abstract
Antimicrobial proteins constitute a phylogenetically ancient form of innate immunity that provides host defence at skin and mucosal surfaces. Although some components of this system are constitutively expressed, new evidence reviewed in this Progress article shows that the production of certain antimicrobial proteins by epithelial cells can also be regulated by cytokines of the innate and adaptive immune systems. In particular, the effector cytokines interleukin-17 and interleukin-22, which are produced by the T-helper-17-cell subset, are emerging as crucial regulators of antimicrobial-peptide production in the gut and the lungs. This suggests that this T-cell lineage and its cytokines have important roles in skin and mucosal immunity.
Details
- Title: Subtitle
- Cytokine-mediated regulation of antimicrobial proteins
- Creators
- Jay K Kolls - Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USAPaul B McCray - Division of Allergy and Pulmonology, Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USAYvonne R Chan - Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Immunology, Vol.8(11), pp.829-835
- DOI
- 10.1038/nri2433
- PMID
- 18949018
- PMCID
- PMC2901862
- NLM abbreviation
- Nat Rev Immunol
- ISSN
- 1474-1733
- eISSN
- 1474-1741
- Language
- English
- Date published
- 11/2008
- Academic Unit
- Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984093363202771
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