Cytokine mediation of experimental heart failure-induced anhedonia

Angela J Grippo; Joseph Francis; Robert M Weiss; Robert B Felder; Alan Kim Johnson

doi:10.1152/ajpregu.00430.2002

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Cytokine mediation of experimental heart failure-induced anhedonia

Journal article

Peer reviewed

Cytokine mediation of experimental heart failure-induced anhedonia

Angela J Grippo, Joseph Francis, Robert M Weiss, Robert B Felder and Alan Kim Johnson

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(3), pp.R666-R673

03/2003

DOI: 10.1152/ajpregu.00430.2002

PMID: 12611391

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Abstract

Immune system dysfunction is hypothesized to influence several disease states, including cardiovascular disease and psychological depression. The comorbidity of depression and coronary artery disease may be influenced by immune system-brain interactions involving proinflammatory cytokines. The present studies evaluated an index of depression in a rodent model of heart failure by measuring responses to rewarding electrical brain stimulation, which provides an experimental procedure to operationally define anhedonia in rats. Heart failure led to a rightward shift in the current-response relationship in the brain stimulation paradigm, indicative of reduced rewarding properties of the brain stimulation (i.e., anhedonia). Acute treatment with a tumor necrosis factor antagonist, etanercept, reduced circulating tumor necrosis factor- levels in rats with heart failure and restored responding for electrical brain stimulation. The current findings have implications for the study of pathophysiological mechanisms underlying the association of cardiovascular disease and depression.

Tumor Necrosis Factor-alpha - metabolism

Depression - physiopathology

Electric Stimulation

Brain - physiopathology

Rats

Behavior, Animal - physiology

Male

Rats, Sprague-Dawley

Depression - etiology

Animals

Etanercept

Receptors, Tumor Necrosis Factor

Immunoglobulin G - pharmacology

Behavior, Animal - drug effects

Reward

Heart Failure - psychology

Immunosuppressive Agents - pharmacology

Tumor Necrosis Factor-alpha - antagonists & inhibitors

Details

Title: Subtitle: Cytokine mediation of experimental heart failure-induced anhedonia
Creators: Angela J Grippo - Department of Psychology, The University of Iowa, Iowa City, Iowa 52242, USA
Joseph Francis
Robert M Weiss
Robert B Felder
Alan Kim Johnson
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(3), pp.R666-R673
DOI: 10.1152/ajpregu.00430.2002
PMID: 12611391
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: American Physiological Society; United States
Grant note: GM-07069 / NIGMS NIH HHS HL-57472 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-63915 / NHLBI NIH HHS
Language: English
Date published: 03/2003
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984065378402771

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