Journal article
Cytokine polymorphisms and gastric cancer risk: an evolving view
Cancer biology & therapy, Vol.7(2), pp.157-162
02/2008
DOI: 10.4161/cbt.7.2.5270
PMID: 18059184
Abstract
More than 20 years after the identification of Helicobacter pylori as a human pathogen, gastric cancer continues to be a leading cause of cancer deaths worldwide. Genetic association studies have the potential for helping to identify those at greatest risk for developing gastric cancer subsequent to infection by H. pylori. IL1B promoter polymorphisms have been supported by several meta-analyses as being associated with gastric cancer risk. In this review, we discuss challenges in experimental design of gene association studies in gastric cancer, with attention to gene-environment interactions that may lead to inconsistency in findings across populations.
Details
- Title: Subtitle
- Cytokine polymorphisms and gastric cancer risk: an evolving view
- Creators
- Barbara G Schneider - Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. barbara.schneider@vanderbilt.eduM Constanza CamargoKelli K RyckmanLiviu A SicinschiM Blanca PiazueloJovanny ZabaletaPelayo CorreaScott M Williams
- Resource Type
- Journal article
- Publication Details
- Cancer biology & therapy, Vol.7(2), pp.157-162
- Publisher
- United States
- DOI
- 10.4161/cbt.7.2.5270
- PMID
- 18059184
- ISSN
- 1538-4047
- eISSN
- 1555-8576
- Grant note
- P01CA028842 / NCI NIH HHS
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9983995110702771
Metrics
15 Record Views