Journal article
Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV
Journal of medical virology, Vol.89(11), pp.1904-1911
11/2017
DOI: 10.1002/jmv.24836
PMCID: PMC5603382
PMID: 28460153
Abstract
A beneficial impact of the Human Pegivirus (HPgV)-formerly called GB virus C (GBV-C)-on HIV disease progression has been reported previously. One possible mechanism by which HPgV inhibits HIV replication is an alteration of the cytokine/chemokine milieu. Their expression has not been specifically evaluated in women despite their influence on disease progression and the possibility of gender-based differences in expression. Moreover, the impact of HPgV genotype on cytokine/chemokine expression is unknown. Sera levels of IL-2, IL-4, IL-7, IL-8, IL-10, IL-12p70, IL-13, IFNγ, TNFα, IP-10, MIP-1α, MIP-1β, and TGF-β
were quantified in 150 HIV-positive women based on HPgV RNA status. Cytokines/chemokines with detection rates of at least 50% included IL-2, IL-4, IL-8, IL-10, IL-12p70, IFNγ, TNFα, IP-10, MIP-1α, MIP-1β, and TGF-β
. Absolute values were significantly higher for HPgV positive compared to HPgV negative women for IL-7, IL-13, IL-12p70, and IFNγ. Absolute values were significantly lower for HPgV positive women for IL-4, IL-8, TGF-β
, and IP-10. IFNγ values were higher for HPgV genotype 2 than for genotype 1 (P = 0.036). Further study of cytokine/chemokine regulation by HPgV may ultimately lead to the development of novel therapeutic agents to treat HIV infection and/or the design of vaccine strategies that mimic the "protective" effects of HPgV replication.
Details
- Title: Subtitle
- Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV
- Creators
- Jason T Blackard - University of Cincinnati Medical CenterGang Ma - University of Cincinnati Medical CenterJeffrey A Welge - University of Cincinnati Medical CenterLynn E Taylor - Miriam HospitalKenneth H Mayer - Fenway HealthRobert S Klein - Hudson Infectious Diseases Associates, Briarcliff Manor, New YorkDavid D Celentano - Johns Hopkins UniversityJack D Sobel - Wayne State UniversityDenise J Jamieson - Centers for Disease Control and PreventionCaroline C King - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- Journal of medical virology, Vol.89(11), pp.1904-1911
- DOI
- 10.1002/jmv.24836
- PMID
- 28460153
- PMCID
- PMC5603382
- ISSN
- 0146-6615
- eISSN
- 1096-9071
- Grant note
- R21 AI081564 / NIAID NIH HHS
- Language
- English
- Date published
- 11/2017
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446516002771
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