Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study

Atif Zafar; Mudassir Farooqui; Asad Ikram; Sajid Suriya; Duraisamy Kempuraj; Mohammad Khan; Nudrat Tasneem; Dania Qaryouti; Syed Quadri; Harold P Adams; Santiago Ortega-Gutierrez; Enrique Leira; Asgar Zaheer

doi:10.25259/SNI_569_2021

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Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study

Journal article

Open access

Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study

Atif Zafar, Mudassir Farooqui, Asad Ikram, Sajid Suriya, Duraisamy Kempuraj, Mohammad Khan, Nudrat Tasneem, Dania Qaryouti, Syed Quadri, Harold P Adams, …

Surgical neurology international, Vol.12, 366

07/27/2021

DOI: 10.25259/SNI_569_2021

PMCID: PMC8422456

PMID: 34513133

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Abstract

Immunomodulation and cell signaling involve several cytokines, proteins, and other mediators released in response to the trauma, inflammation, or other insults to the central nervous system. This pilot study is part of the registry designed to evaluate the temporal trends among these molecules after an acute ischemic stroke (AIS) in patients. Twelve AIS patients were enrolled within 24 hours of the symptoms onset. Two sets of plasma samples were collected: First at admission and second at 24 hours after admission. Cytokines/chemokines and other inflammatory molecules were measured using multiplex assay kit. An increased trend in IL-6 (22 vs. 34 pg/ml), IL-8/CXCL8 (87 vs. 98 pg/ml), MMP-9 (16225 vs. 18450 pg/ml), and GMF-β (999 vs. 3739 pg/ml) levels was observed overtime after an AIS. Patients ≤60 years had lower levels of plasma MCP-1/CCL2 (50-647 vs. 150-1159 pg/ml), IL-6 (9-25 vs. 20-68 pg/ml), and IL-8 (30- 143 vs. 72-630 pg/ml), when compared with patients >60 years old. Cytokines/chemokines and other inflammatory mediators play an important role in the pathogenesis of stroke in addition to mediating poststroke inflammation. Further research is needed to evaluate and characterize the cumulative trends of these mediators for the clinical prognosis or as surrogate biomarkers.

Stroke

Acute ischemic brain injury

Interleukin

Cytokine

Poststroke inflammation

Details

Title: Subtitle: Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study
Creators: Atif Zafar - University of Toronto
Mudassir Farooqui - University of Iowa
Asad Ikram - Department of Neurology, University of New Mexico, Albuquerque, New Mexico
Sajid Suriya - Department of Neurology, University of New Mexico, Albuquerque, New Mexico
Duraisamy Kempuraj - University of Missouri
Mohammad Khan - Department of Neurology, University of Tennessee, Memphis, Tennessee
Nudrat Tasneem - Department of Neurology, University of Iowa, Iowa City, Iowa
Dania Qaryouti - Department of Neurology, University of New Mexico, Albuquerque, New Mexico
Syed Quadri - Massachusetts General Hospital
Harold P Adams - University of Iowa
Santiago Ortega-Gutierrez - University of Iowa
Enrique Leira - University of Iowa
Asgar Zaheer - University of Missouri
Resource Type: Journal article
Publication Details: Surgical neurology international, Vol.12, 366
DOI: 10.25259/SNI_569_2021
PMID: 34513133
PMCID: PMC8422456
NLM abbreviation: Surg Neurol Int
ISSN: 2229-5097
Language: English
Date published: 07/27/2021
Academic Unit: Neurology; Radiology; Epidemiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984252349402771

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