Journal article
Cytological Anal Squamous Intraepithelial Lesions Associated with Anal High-Risk Human Papillomavirus Infections among Men Who Have Sex with Men in Northern Thailand
PloS one, Vol.11(5), pp.e0156280-e0156280
2016
DOI: 10.1371/journal.pone.0156280
PMCID: PMC4882004
PMID: 27227684
Abstract
Anal cancer, one of human papillomavirus (HPV) related malignancies, has increased in recent decades, particularly among men who have sex with men (MSM) and HIV-infected (HIV+) persons. We aimed to explore the prevalence of anal squamous intraepithelial lesions (ASIL) using Papanicolau (Pap) screening among MSM in northern Thailand and its associated factors.
Two hundreds MSM aged ≥18 years reporting receptive anal intercourse in the prior 6 months were recruited from July 2012 through January 2013. Medical history and behavioral data were collected by staff interview and computer-assisted self interview. Anal Pap smear, HPV genotyping, and HIV testing were performed. Two pathologists blinded to HPV and HIV status reported cytologic results by Bethesda classification.
Mean age was 27.2 years (range 18-54). Overall, 86 (43.0%) had ASIL: 28 (14.2%) with atypical cells of undetermined significance (ASCUS), 1 (0.5%) with atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H), 56 (28.4%) with low-grade squamous intraepithelial lesion (LSIL), and 1 (0.5%) with high-grade squamous intraepithelial lesion (HSIL). ASIL was associated by univariate analysis (p ≤0.05) with older age, gender identity other than bisexual (i.e., gay men and transgender women), rectal douching, anal symptoms, genital warts, HIV positivity, and high-risk-HPV infection. However, on multiple logistic regression ASIL was associated only with high-risk HPV type (p = 0.002) and HIV infection (p = 0.01).
ASIL is quite common in high-risk MSM in northern Thailand and is associated with high-risk HPV types and HIV infection. Routine anal Pap screening should be considered, given the high frequency of ASIL, particularly in the HIV+. High resolution anoscopy (HRA), not done here, should be to confirm PAP smears whose sensitivity and specificity are quite variable. Timely HPV vaccination should be considered for this population.
Details
- Title: Subtitle
- Cytological Anal Squamous Intraepithelial Lesions Associated with Anal High-Risk Human Papillomavirus Infections among Men Who Have Sex with Men in Northern Thailand
- Creators
- Darin Ruanpeng - Chiang Mai UniversitySuwat Chariyalertsak - Chiang Mai UniversityQuanhathai Kaewpoowat - Chiang Mai UniversityTaweewat Supindham - Chiang Mai UniversityJongkolnee Settakorn - Chiang Mai UniversityKornkanok Sukpan - Chiang Mai UniversityUtaiwan Utaipat - Chiang Mai UniversityToshiyuki Miura - Nagasaki UniversityNatthapol Kosashunhanan - Chiang Mai UniversityPongpun Saokhieo - Chiang Mai UniversityRadchanok Songsupa - Chiang Mai UniversityAntika Wongthanee - Chiang Mai University
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.11(5), pp.e0156280-e0156280
- DOI
- 10.1371/journal.pone.0156280
- PMID
- 27227684
- PMCID
- PMC4882004
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Grant note
- name: Grant-in-Aid for Scientific Research (B), award: 23406032; name: Thailand National Research University Project
- Language
- English
- Date published
- 2016
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359913002771
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