Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States

A R Prossin; R H Yolken; M Kamali; M M Heitzeg; J B Kaplow; W H Coryell; M G McInnis

doi:10.1155/2015/939780

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Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States

Journal article

Open access

Peer reviewed

Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States

A R Prossin, R H Yolken, M Kamali, M M Heitzeg, J B Kaplow, W H Coryell and M G McInnis

Neural plasticity, Vol.2015, 939780

2015

DOI: 10.1155/2015/939780

PMCID: PMC4444593

PMID: 26075105

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Abstract

The neurobiology of mood states is complicated by exposure to everyday stressors (e.g., psychosocial, ubiquitous environmental infections like CMV), each fluctuating between latency and reactivation. CMV reactivation induces proinflammatory cytokines (e.g., TNF-α) associated with induction of neurotoxic metabolites and the presence of mood states in bipolar disorder (BD). Whether CMV reactivation is associated with bipolar diagnoses (trait) or specific mood states is unclear. We investigated 139 BD type I and 99 healthy controls to determine if concentrations of IgG antibodies to Herpesviridae (e.g., CMV, HSV-1, and HSV-2) were associated with BD-I diagnosis and specific mood states. We found higher CMV antibody concentration in BD-I than in healthy controls (T234 = 3.1, P uncorr = 0.002; P corr = 0.006) but no difference in HSV-1 (P > 0.10) or HSV-2 (P > 0.10). Compared to euthymic BD-I volunteers, CMV IgG was higher in BD-I volunteers with elevated moods (P < 0.03) but not different in depressed moods (P > 0.10). While relationships presented between BD-I diagnosis, mood states, and CMV antibodies are encouraging, they are limited by the study's cross sectional nature. Nevertheless, further testing is warranted to replicate findings and determine whether reactivation of CMV infection exacerbates elevated mood states in BD-I.

Immunoglobulin G - blood

Affect - physiology

Humans

Adult

Bipolar Disorder - complications

Female

Male

Cytomegalovirus Infections - complications

Cytomegalovirus Infections - immunology

Cytomegalovirus Infections - diagnosis

Antibodies, Viral - blood

Bipolar Disorder - virology

Details

Title: Subtitle: Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States
Creators: A R Prossin - Department of Psychiatry, University of Texas Health Science Center at Houston, 1941 East Road, No. 2308, Houston, TX 77054, USA ; Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
R H Yolken - Stanley Laboratory of Developmental Neurovirology, Johns Hopkins University Medical Center, Baltimore, MD 21287, USA
M Kamali - Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
M M Heitzeg - Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J B Kaplow - Department of Psychiatry, University of Texas Health Science Center at Houston, 1941 East Road, No. 2308, Houston, TX 77054, USA
W H Coryell - Department of Psychiatry, University of Iowa School of Medicine, Iowa City, IA 52242, USA
M G McInnis - Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Resource Type: Journal article
Publication Details: Neural plasticity, Vol.2015, 939780
DOI: 10.1155/2015/939780
PMID: 26075105
PMCID: PMC4444593
NLM abbreviation: Neural Plast
ISSN: 2090-5904
eISSN: 1687-5443
Publisher: United States
Grant note: R00 DA033454 / NIDA NIH HHS K99 DA033454 / NIDA NIH HHS
Language: English
Date published: 2015
Academic Unit: Psychiatry
Record Identifier: 9984003444502771

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