Journal article
Cytomegalovirus IgG Level and Avidity in Breastfeeding Infants of HIV-Infected Mothers in Malawi
Clinical and vaccine immunology, Vol.22(12), pp.1222-1226
12/01/2015
DOI: 10.1128/CVI.00460-15
PMCID: PMC4658584
PMID: 26424831
Abstract
Cytomegalovirus (CMV) infection is common among infants of HIV-infected mothers in resource-limited settings. We examined the prevalence and timing of infant CMV infection during the first year of life using IgG antibody and avidity among HIV-exposed infants in Malawi and correlated the results with the presence of detectable CMV DNA in the blood. The Breastfeeding, Antiretrovirals and Nutrition (BAN) study randomized 2,369 mothers and their infants to maternal antiretrovirals, infant nevirapine, or neither for 28 weeks of breastfeeding, followed by weaning. Stored plasma specimens were tested for CMV IgG and antibody avidity from a random subset of infants who had been previously tested with blood CMV PCR and had available specimens at birth and at 24 and 48 weeks of age. Ninety-four of 127 infants (74.0%) tested at 24 weeks of age had CMV IgG of low or intermediate avidity, signifying primary CMV infections. An additional 22 infants (17.3%) had IgG of high avidity; 19 of them had CMV DNA detected in their blood, indicating infant infections. Taken together, these results show that the estimated prevalence of CMV infection at 24 weeks was 88.9%. By 48 weeks of age, 81.3% of infants had anti-CMV IgG; most of them (70.9%) had IgG of high avidity. The CMV serology and avidity testing, combined with the PCR results, confirmed a high rate of primary CMV infection by 6 months of life among breastfeeding infants of HIV-infected mothers. The CMV PCR in blood detected most, but not all, infant CMV infections.
Details
- Title: Subtitle
- Cytomegalovirus IgG Level and Avidity in Breastfeeding Infants of HIV-Infected Mothers in Malawi
- Creators
- Athena P Kourtis - Centers for Disease Control and PreventionJeffrey Wiener - Centers for Disease Control and PreventionTiffany S Chang - Emory University School of MedicineSheila C Dollard - Centers for Disease Control and PreventionMinal M Amin - Centers for Disease Control and PreventionSascha Ellington - Centers for Disease Control and PreventionDumbani Kayira - UNC Project, Lilongwe, MalawiCharles van der Horst - University of North Carolina at Chapel HillDenise J Jamieson - Centers for Disease Control and PreventionBreastfeeding, Antiretrovirals and Nutrition (BAN) study team
- Resource Type
- Journal article
- Publication Details
- Clinical and vaccine immunology, Vol.22(12), pp.1222-1226
- DOI
- 10.1128/CVI.00460-15
- PMID
- 26424831
- PMCID
- PMC4658584
- ISSN
- 1556-6811
- eISSN
- 1556-679X
- Grant note
- R24 TW00798 / FIC NIH HHS U48-CCU409660-09 / PHS HHS 2-D43 TW01039-06 / FIC NIH HHS P30 AI050410 / NIAID NIH HHS U48 DP001944 / NCCDPHP CDC HHS P30-AI50410 / NIAID NIH HHS U48 DP000059 / NCCDPHP CDC HHS U48-DP000059-01 / NCCDPHP CDC HHS U48-DP001944-01 / NCCDPHP CDC HHS
- Language
- English
- Date published
- 12/01/2015
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446272902771
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