Cytomegalovirus infection in a cyclosporine-treated burn patient : case report

J. F Bale; G. P Kealey; C. L Ebelhack; C. E Platz; J. A Goeken

doi:10.1097/00005373-199202000-00026

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Journal article

Cytomegalovirus infection in a cyclosporine-treated burn patient : case report

J. F Bale, G. P Kealey, C. L Ebelhack, C. E Platz and J. A Goeken

The journal of trauma, Vol.32(2), pp.263-267

1992

DOI: 10.1097/00005373-199202000-00026

PMID: 1311042

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Abstract

We report the case of a 45-year-old burned man (55% total body surface area full-thickness burn) who developed symptomatic cytomegalovirus infection during cyclosporine (CSA) therapy (3 mg/kg orally) for skin transplantation. During the sixth hospital week the patient developed signs compatible with CMV infection, and CMV was recovered from the urine and sputum. Examination of skin biopsy specimens from the transplanted cadaver allograft revealed inclusion bodies compatible with CMV infection, and CMV antigens were detected by immunohistochemical testing. The CMV infection of the skin was confirmed by recovery of infectious virus and by detection of CMV nucleic acids using in situ hybridization with a biotinylated HCMV DNA probe. Restriction enzyme analysis of a urine CMV isolate and two isolates from skin demonstrated differences in DNA patterns, suggesting that the patient was infected simultaneously with two different CMV strains. © 1992 by Williams & Wilkins.

Infectious Diseases

Biological and medical sciences

Human viral diseases

Medical sciences

Viral diseases

Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye

Details

Title: Subtitle: Cytomegalovirus infection in a cyclosporine-treated burn patient : case report
Creators: J. F Bale - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United States
G. P Kealey - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United States
C. L Ebelhack - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United States
C. E Platz - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United States
J. A Goeken - Univ. Iowa coll. medicine, dep. pediatrics, Iowa city IA 52242, United States
Resource Type: Journal article
Publication Details: The journal of trauma, Vol.32(2), pp.263-267
Publisher: Lippincott Williams & Wilkins
DOI: 10.1097/00005373-199202000-00026
PMID: 1311042
ISSN: 0022-5282
eISSN: 1529-8809
Language: English
Date published: 1992
Academic Unit: Pathology; Surgery
Record Identifier: 9984204114402771

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