Journal article
Cytomegalovirus modulates interleukin-6 gene expression
Transplantation, Vol.62(5), pp.653-658
1996
DOI: 10.1097/00007890-199609150-00020
PMID: 8830832
Abstract
Complications after lung transplantation include the development of rejection and an increased incidence of infection, particularly with cytomegalovirus (CMV). Several recent studies have suggested that interleukin (IL)-6 may be used to detect both infection and rejection after lung transplantation. In addition, IL-6 may play a role in the development of bronchiolitis obliterans after transplantation. Because CMV is also associated with the development of bronchiolitis obliterans after transplantation, we determined whether CMV induces IL-6 gene expression. We demonstrated that CMV infection increased both IL-6 protein and mRNA in peripheral blood mononuclear cells. We also demonstrated that the CMV immediate early 1 gene product increased expression of the IL-6 promoter. This effect of the CMV immediate early 1 gene product was dependent upon the presence of specific transcription factor binding sites in the IL-6 promoter. These studies demonstrate that CMV may be an important cofactor in the development of rejection and infection after transplantation through its effects on IL-6.
Details
- Title: Subtitle
- Cytomegalovirus modulates interleukin-6 gene expression
- Creators
- L J Geist - Department of Medicine, University of Iowa College of Medicine and the Department of Veterans Affairs, Iowa City, Iowa 52242, United StatesL Y Dai - Department of Medicine, University of Iowa College of Medicine and the Department of Veterans Affairs, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.62(5), pp.653-658
- Publisher
- Lippincott
- DOI
- 10.1097/00007890-199609150-00020
- PMID
- 8830832
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Language
- English
- Date published
- 1996
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Provost Office Administration; Internal Medicine
- Record Identifier
- 9984094771602771
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