Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices

J R Murph; James F Bale Jr; J C Murray; M F Stinski; S Perlman

doi:10.1016/S0022-3476(86)80568-6

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Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices

Journal article

Peer reviewed

Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices

J R Murph, James F Bale Jr, J C Murray, M F Stinski and S Perlman

The Journal of pediatrics, Vol.109(1), pp.35-39

07/1986

DOI: 10.1016/S0022-3476(86)80568-6

PMID: 3014103

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Abstract

The epidemiology of cytomegalovirus (CMV) infection and transmission in a large Iowa day care center was studied. Over the 9 months of the study the overall CMV prevalence rates were 21% to 22%, with rates as high as 71% in toddlers. Titers of CMV in the urine or saliva of infected children were as high as 3 X 10(4) plaque-forming units of CMV per milliliter, similar to titers of CMV observed in some congenitally infected infants. Restriction enzyme analysis of CMV isolates from children in the center demonstrated two major clusters with similar patterns, one among 2- and 3-year-old children and another among infants. The clustering of similar CMV isolates among nonambulatory infants suggests that child care or hygienic practices may contribute to the spread of CMV infection in day care centers. Furthermore, the relatively high prevalence of CMV excretion in this center and the low seropositivity rates to CMV among adults in Iowa suggest that adults in the Midwest who have contact with children in day care centers may be at risk for primary CMV infection.

Child Care

Genetic Markers

Cytomegalovirus - isolation & purification

Child Day Care Centers

Cytomegalovirus Infections - epidemiology

Humans

Child, Preschool

Infant

Iowa

DNA Restriction Enzymes

Saliva - microbiology

Cytomegalovirus Infections - transmission

Child

Details

Title: Subtitle: Cytomegalovirus transmission in a Midwest day care center: possible relationship to child care practices
Creators: J R Murph
James F Bale Jr
J C Murray
M F Stinski
S Perlman
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.109(1), pp.35-39
DOI: 10.1016/S0022-3476(86)80568-6
PMID: 3014103
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Publisher: United States
Language: English
Date published: 07/1986
Academic Unit: Microbiology and Immunology; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Infectious Disease (Pediatrics)
Record Identifier: 9983777352502771

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