Journal article
Cytoplasmic expression of CD133 sternness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma
Experimental and molecular pathology, Vol.103(2), pp.218-228
10/01/2017
DOI: 10.1016/j.yexmp.2017.10.001
Abstract
Prominin-1 (CD133) is one of the most commonly used markers for cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. However, the clinical and prognostic significance of CSCs in renal cell carcinoma (RCC) remains unclear. The aim of this study was to investigate the expression patterns and prognostic significance of the cancer stem cell marker CD133 in different histological subtypes of RCC. CD133 expression was evaluated using immunohistochemistry in 193 well-defined renal tumor samples on tissue microarrays, including 136 (70.5%) clear cell renal cell carcinomas (CCRCCs), 26 (13.5%) papillary RCC5, and 31 (16.1%) chromophobe RCCs. The association between CD133 expression and clinicopathological features as well as the survival outcomes was determined. There was a statistically significant difference between CD133 expression among the different RCC subtypes. In CCRCC, higher cytoplasmic expression of CD133 was significantly associated with increase in grade, stage, microvascular invasion (MVI) and lymph node invasion (LNI), while no association was found with the membranous expression. Moreover, on multivariate analysis, TNM stage and nuclear grade were independent prognostic factors for overall survival (OS) in cytoplasmic expression. We showed that higher cytoplasmic CD133 expression was associated with more aggressive tumor behavior and more advanced disease in CCRCC but not in the other examined subtypes. Our results demonstrated that higher cytoplasmic CD133 expression is clinically significant in CCRCC and is associated with increased tumor aggressiveness and is useful for predicting cancer progression.
Details
- Title: Subtitle
- Cytoplasmic expression of CD133 sternness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma
- Creators
- Leili Saeednejad Zanjani - Iran University of Medical SciencesZahra Madjd - Iran University of Medical SciencesMaryam Abolhasani - Iran University of Medical SciencesYvonne Andersson - Oslo University HospitalArezoo Rasti - Iran University of Medical SciencesAhmad Shariftabrizi - University at Buffalo, State University of New YorkMojgan Asgari - Iran University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Experimental and molecular pathology, Vol.103(2), pp.218-228
- Publisher
- Elsevier
- DOI
- 10.1016/j.yexmp.2017.10.001
- ISSN
- 0014-4800
- eISSN
- 1096-0945
- Number of pages
- 11
- Grant note
- 25239 / Iran University of Medical Sciences
- Language
- English
- Date published
- 10/01/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984318719002771
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