Journal article
Cytosolic sulfotransferases in endocrine disruption
Essays in biochemistry, Vol.68(4), pp.541-553
05/03/2024
DOI: 10.1042/EBC20230101
PMCID: PMC11531609
PMID: 38699885
Appears in UI Libraries Support Open Access
Abstract
The mammalian cytosolic sulfotransferases (SULTs) catalyze the sulfation of endocrine hormones as well as a broad array of drugs, environmental chemicals, and other xenobiotics. Many endocrine-disrupting chemicals (EDCs) interact with these SULTs as substrates and inhibitors, and thereby alter sulfation reactions responsible for metabolism and regulation of endocrine hormones such as estrogens and thyroid hormones. EDCs or their metabolites may also regulate expression of SULTs through direct interaction with nuclear receptors and other transcription factors. Moreover, some sulfate esters derived from EDCs (EDC-sulfates) may serve as ligands for endocrine hormone receptors. While the sulfation of an EDC can lead to its excretion in the urine or bile, it may also result in retention of the EDC-sulfate through its reversible binding to serum proteins and thereby enable transport to other tissues for intracellular hydrolysis and subsequent endocrine disruption. This mini-review outlines the potential roles of SULTs and sulfation in the effects of EDCs and our evolving understanding of these processes.
Details
- Title: Subtitle
- Cytosolic sulfotransferases in endocrine disruption
- Creators
- Michael W Duffel - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Essays in biochemistry, Vol.68(4), pp.541-553
- DOI
- 10.1042/EBC20230101
- PMID
- 38699885
- PMCID
- PMC11531609
- NLM abbreviation
- Essays Biochem
- eISSN
- 1744-1358
- Publisher
- Portland Press
- Grant note
- NIH P42 ES013661 / National Institutes of Health (NIH) NIH P30 ES005605 / National Institutes of Health (NIH)
- Language
- English
- Date published
- 05/03/2024
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984622889002771
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