Journal article
D-methionine (D-met) significantly rescues noise-induced hearing loss: Timing studies
Hearing research, Vol.282(1-2), pp.138-144
12/01/2011
DOI: 10.1016/j.heares.2011.08.003
PMID: 21924333
Abstract
We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with D-methionine (D-met) administration 1 h after noise exposure. The present study investigated further D-met rescue intervals at 3, 5 and 7 h post-noise exposure. Chinchillas laniger were exposed to a 6 h 105 dB sound pressure level (dB SPL) octave band noise (OBN) and then administered D-met i.p. starting 3, 5, or 7 h after noise exposure: controls received saline i.p. immediately after noise exposure. ABR assessments were performed at baseline and on post-exposure days 1 and 21. Outer hair cell (OHC) loss was measured in cochleae obtained at sacrifice 21 days post-exposure. Administration of D-met starting at any of the delay times of 3-7 h post-noise exposure significantly reduced day 21 ABR threshold shift at 2 and 4 kHz and OHC loss at all hair cell regions measured (2, 4, 6 and 8 kHz). ABR threshold shifts in the control group at 6 and 8 kHz were only 8 and 11 dB respectively allowing little opportunity to observe protection at those 2 frequencies. (C) 2011 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- D-methionine (D-met) significantly rescues noise-induced hearing loss: Timing studies
- Creators
- Kathleen Campbell - Southern Illinois University School of MedicineAlex Claussen - Southern Illinois University School of MedicineRobert Meech - Southern Illinois University School of MedicineSteven Verhulst - Southern Illinois University School of MedicineDaniel Fox - Southern Illinois University School of MedicineLarry Hughes - Southern Illinois University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Hearing research, Vol.282(1-2), pp.138-144
- Publisher
- Elsevier
- DOI
- 10.1016/j.heares.2011.08.003
- PMID
- 21924333
- ISSN
- 0378-5955
- eISSN
- 1878-5891
- Number of pages
- 7
- Grant note
- Illinois Excellence in Academic Medicine Grant Program Mentored Professional Enrichment Experience Program
- Language
- English
- Date published
- 12/01/2011
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984366372602771
Metrics
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