D1-dependent 4 Hz oscillations and ramping activity in rodent medial frontal cortex during interval timing

Krystal L Parker; Kuan-Hua Chen; Johnathan R Kingyon; James F Cavanagh; Nandakumar S Narayanan

doi:10.1523/JNEUROSCI.2772-14.2014

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D1-dependent 4 Hz oscillations and ramping activity in rodent medial frontal cortex during interval timing

Journal article

Open access

Peer reviewed

D1-dependent 4 Hz oscillations and ramping activity in rodent medial frontal cortex during interval timing

Krystal L Parker, Kuan-Hua Chen, Johnathan R Kingyon, James F Cavanagh and Nandakumar S Narayanan

The Journal of neuroscience, Vol.34(50), pp.16774-166783

12/10/2014

DOI: 10.1523/JNEUROSCI.2772-14.2014

PMCID: PMC4261101

PMID: 25505330

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Abstract

Organizing behavior in time is a fundamental process that is highly conserved across species. Here we study the neural basis of timing processes. First, we found that rodents had a burst of stimulus-triggered 4 Hz oscillations in the medial frontal cortex (MFC) during interval timing tasks. Second, rodents with focally disrupted MFC D1 dopamine receptor (D1DR) signaling had impaired interval timing performance and weaker stimulus-triggered oscillations. Prior work has demonstrated that MFC neurons ramp during interval timing, suggesting that they underlie temporal integration. We found that MFC D1DR blockade strongly attenuated ramping activity of MFC neurons that correlated with behavior. These macro- and micro-level phenomena were linked, as we observed that MFC neurons with strong ramping activity tended to be coherent with stimulus-triggered 4 Hz oscillations, and this relationship was diminished with MFC D1DR blockade. These data provide evidence demonstrating how D1DR signaling controls the temporal organization of mammalian behavior.

Animals

Biological Clocks - physiology

Receptors, Dopamine D1 - physiology

Rats, Long-Evans

Neurons - physiology

Conditioning, Operant - physiology

Rats

Male

Brain Mapping - methods

Reaction Time - physiology

Frontal Lobe - physiology

Details

Title: Subtitle: D1-dependent 4 Hz oscillations and ramping activity in rodent medial frontal cortex during interval timing
Creators: Krystal L Parker - Department of Neurology and
Kuan-Hua Chen - Department of Neurology and
Johnathan R Kingyon - Department of Neurology and
James F Cavanagh - Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131
Nandakumar S Narayanan - Department of Neurology and Aging Mind and Brain Initiative, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, and nandakumar-narayanan@uiowa.edu
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.34(50), pp.16774-166783
DOI: 10.1523/JNEUROSCI.2772-14.2014
PMID: 25505330
PMCID: PMC4261101
NLM abbreviation: J Neurosci
ISSN: 0270-6474
eISSN: 1529-2401
Publisher: United States
Grant note: K08 NS078100 / NINDS NIH HHS R01 NS089470 / NINDS NIH HHS
Language: English
Date published: 12/10/2014
Academic Unit: Neurology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003486002771

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