Journal article
D20 Operationalising compensation over time in neurodegenerative disease
Journal of neurology, neurosurgery and psychiatry, Vol.87(Suppl 1), pp.A41-A41
09/2016
DOI: 10.1136/jnnp-2016-314597.119
Abstract
Compensation is a concept that has been introduced in neurodegeneration to account for the common observation that macroscopic neurodegeneration is frequently evident in brain imaging many years prior to symptom onset with little or no deterioration in behaviour. It is proposed that this dissociation between brain pathology and normal behaviour early in neurodegenerative disease reflects some kind of neuronal compensation. However, models of compensation are often conceptual and not operationalised in a form that readily permits them to be tested.Recent reviews have proposed that to characterise compensation fully three different components and their relationship should be considered: brain activity, behaviour and pathology. We have previously devised an operational model of compensation that focusses on the relationship between brain activity and behaviour as a function of structural measures of disease load and successfully applied this to cross-sectional functional and structural imaging data obtained from the preclinical TrackOn-HD cohort.1However, we postulate that compensatory behaviours in response to brain disease will change differentially over time, dependent on changes in neuronal pathology and existing motor and cognitive deficits. In such a situation, investigation of compensation at a single time point will not provide an adequate characterisation of compensation. We now extend our cross-sectional models to account for the longitudinal change characteristic of neurodegeneration and examine the theoretical and conceptual underpinnings. We consider two approaches to measuring longitudinal compensation. First, estimation of average compensation over time accounting for dependence due to repeated measures and second, estimation of change in compensation over time.ReferenceKloppel S, Gregory S. Compensation in preclinical Huntington’s disease: evidence from the Track-On HD study. E Bio Medicine 2015
Details
- Title: Subtitle
- D20 Operationalising compensation over time in neurodegenerative disease
- Creators
- Sarah Gregory - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaJeffrey D Long - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaStefan Klöppel - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaAdeel Razi - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaElisa Scheller - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaLora Minkova - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaMarina Papoutsi - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaJames A Mills - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaJulie Stout - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaRachael I Scahill - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaDouglas R Langbehn - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaSarah J Tabrizi - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, AustraliaGeraint Rees - School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, Australia
- Resource Type
- Journal article
- Publication Details
- Journal of neurology, neurosurgery and psychiatry, Vol.87(Suppl 1), pp.A41-A41
- DOI
- 10.1136/jnnp-2016-314597.119
- ISSN
- 0022-3050
- eISSN
- 1468-330X
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Psychiatry; Biostatistics; Iowa Neuroscience Institute
- Record Identifier
- 9984066147002771
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