DDX3X and Stress Granules: Emerging Players in Cancer and Drug Resistance

Han Zhang; Paula M Mañán-Mejías; Hannah N Miles; Andrea A Putnam; Leonard R MacGillivray; William A Ricke

doi:10.3390/cancers16061131

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DDX3X and Stress Granules: Emerging Players in Cancer and Drug Resistance

Journal article

Open access

Peer reviewed

DDX3X and Stress Granules: Emerging Players in Cancer and Drug Resistance

Han Zhang, Paula M Mañán-Mejías, Hannah N Miles, Andrea A Putnam, Leonard R MacGillivray and William A Ricke

Cancers, Vol.16(6), 1131

03/12/2024

DOI: 10.3390/cancers16061131

PMCID: PMC10968774

PMID: 38539466

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https://doi.org/10.3390/cancers16061131View

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Abstract

The DEAD (Asp-Glu-Ala-Asp)-box helicase 3 X-linked (DDX3X) protein participates in many aspects of mRNA metabolism and stress granule (SG) formation. DDX3X has also been associated with signal transduction and cell cycle regulation that are important in maintaining cellular homeostasis. Malfunctions of DDX3X have been implicated in multiple cancers, including brain cancer, leukemia, prostate cancer, and head and neck cancer. Recently, literature has reported SG-associated cancer drug resistance, which correlates with a negative disease prognosis. Based on the connections between DDX3X, SG formation, and cancer pathology, targeting DDX3X may be a promising direction for cancer therapeutics development. In this review, we describe the biological functions of DDX3X in terms of mRNA metabolism, signal transduction, and cell cycle regulation. Furthermore, we summarize the contributions of DDX3X in SG formation and cellular stress adaptation. Finally, we discuss the relationships of DDX3X, SG, and cancer drug resistance, and discuss the current research progress of several DDX3X inhibitors for cancer treatment.

Drug Resistance

DDX3X

stress granule

castration resistance

double-negative prostate cancer

translational repression

novel therapy

Details

Title: Subtitle: DDX3X and Stress Granules: Emerging Players in Cancer and Drug Resistance
Creators: Han Zhang - University of Wisconsin–Madison
Paula M Mañán-Mejías - University of Wisconsin–Madison
Hannah N Miles - University of Wisconsin–Madison
Andrea A Putnam - University of Wisconsin–Madison
Leonard R MacGillivray - University of Iowa
William A Ricke - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Cancers, Vol.16(6), 1131
DOI: 10.3390/cancers16061131
PMID: 38539466
PMCID: PMC10968774
ISSN: 2072-6694
eISSN: 2072-6694
Grant note: DK127081 / NIDDK NIH HHS CA269011 / NCI NIH HHS U54DK104310 / NIDDK NIH HHS DK131175 / NIDDK NIH HHS
Language: English
Date published: 03/12/2024
Academic Unit: Chemistry
Record Identifier: 9984580315702771

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