DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature

Candice C Askwith; Christopher J Benson; Michael J Welsh; Peter M Snyder

doi:10.1073/pnas.111155398

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DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature

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DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature

Candice C Askwith, Christopher J Benson, Michael J Welsh and Peter M Snyder

Proceedings of the National Academy of Sciences - PNAS, Vol.98(11), pp.6459-6463

05/22/2001

DOI: 10.1073/pnas.111155398

PMCID: PMC33490

PMID: 11353858

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Abstract

Several DEG/ENaC cation channel subunits are expressed in the tongue and in cutaneous sensory neurons, where they are postulated to function as receptors for salt and sour taste and for touch. Because these tissues are exposed to large temperature variations, we examined how temperature affects DEG/ENaC channel function. We found that cold temperature markedly increased the constitutively active Na + currents generated by epithelial Na + channels (ENaC). Half-maximal stimulation occurred at 25°C. Cold temperature did not induce current from other DEG/ENaC family members (BNC1, ASIC, and DRASIC). However, when these channels were activated by acid, cold temperature potentiated the currents by slowing the rate of desensitization. Potentiation was abolished by a “Deg” mutation that alters channel gating. Temperature changes in the physiologic range had prominent effects on current in cells heterologously expressing acid-gated DEG/ENaC channels, as well as in dorsal root ganglion sensory neurons. The finding that cold temperature modulates DEG/ENaC channel function may provide a molecular explanation for the widely recognized ability of temperature to modify taste sensation and mechanosensation.

Biological Sciences

Details

Title: Subtitle: DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
Creators: Candice C Askwith - Departments of
Christopher J Benson - Departments of
Michael J Welsh - Departments of
Peter M Snyder - Departments of
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.98(11), pp.6459-6463
DOI: 10.1073/pnas.111155398
PMID: 11353858
PMCID: PMC33490
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 05/22/2001
Academic Unit: Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Neurosurgery; Medicine Administration; Internal Medicine
Record Identifier: 9984013202902771

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